UCSF Center for Integrative Neuroscience and Department of Physiology, University of California San Francisco, San Francisco, CA, 94143, USA.
University of California Berkeley, Berkeley, CA, 94720, USA.
Nat Commun. 2018 Jun 7;9(1):2209. doi: 10.1038/s41467-018-04498-w.
Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specific and general features of experience are simultaneously reinstated remains unknown. We examined hippocampal and prefrontal cortical firing patterns during memory reactivation in rats performing a well-learned foraging task with multiple spatial paths. We found that specific hippocampal place representations are preferentially reactivated with the subset of prefrontal cortical task representations that generalize across different paths. Our results suggest that hippocampal-cortical networks maintain links between stored representations for specific and general features of experience, which could support abstraction and task guidance in mammals.
记忆将特定经验的信息与从这些经验中抽象出来并赋予其上下文的更一般的知识联系起来。在清醒的记忆再激活事件中，代表过去经验特征的海马-皮质活动模式被重新激活，但经验的具体和一般特征的代表是否同时被重新激活尚不清楚。我们在大鼠进行一项具有多个空间路径的熟练觅食任务时，检查了记忆再激活过程中海马和前额皮质的放电模式。我们发现，特定的海马位置表示优先与泛化到不同路径的前额皮质任务表示的子集一起被重新激活。我们的结果表明，海马-皮质网络维持了存储的特定和一般经验特征表示之间的联系，这可能支持哺乳动物的抽象和任务指导。
