健康成年人中水痘带状疱疹病毒抗体的流行情况。

Prevalence of antibodies to varicella zoster virus in healthy adults.

作者信息

Schoub B D, Johnson S, McAnerney J M

出版信息

S Afr Med J. 1985 Jun 8;67(23):929-31.

Abstract

A serological study of immunity to varicella zoster was carried out using an enzyme-linked immunosorbent assay (ELISA) in 244 healthy adult laboratory staff members. The overall immunity was 90%, with a progressive increase from 81% at 20-29 years to 100% at 60 years. Approximately one-third of serologically immune individuals had no certain history of varicella. As the serological test is simple, rapid and reliable, screening for immunity should be carried out in at-risk individuals such as immunosuppressed patients, pregnant women, and laboratory and medical patients, pregnant women, and laboratory and medical personnel who come into contact with sources of virus. Definition of serological status will aid in the rational planning of intervention procedures such as epidemiological control and administration of varicella zoster immune globulin and, when it becomes available, varicella vaccine.

摘要

采用酶联免疫吸附测定（ELISA）法，对244名健康成年实验室工作人员进行了水痘带状疱疹免疫血清学研究。总体免疫率为90%，从20 - 29岁的81%逐步上升至60岁时的100%。约三分之一血清学检测呈免疫状态的个体并无明确的水痘病史。由于血清学检测简单、快速且可靠，应对免疫功能低下患者、孕妇以及接触病毒源的实验室和医疗人员等高危个体进行免疫筛查。血清学状态的界定将有助于合理规划干预措施，如流行病学控制、水痘带状疱疹免疫球蛋白的使用以及（如有）水痘疫苗的接种。