正常成人人群对水痘-带状疱疹病毒的免疫力。

Immunity to varicella-zoster virus in a normal adult population.

作者信息

Ndumbe P M, Macqueen S, Holzel H, Levinsky R J

出版信息

J Med Microbiol. 1985 Aug;20(1):105-11. doi: 10.1099/00222615-20-1-105.

Abstract

Sera from 489 trainee nurses were examined, by the ELISA technique, for the presence of varicella-zoster virus specific antibody; antibody was found in 446 (91.2%). In more detailed investigations of specific immunity in 33 healthy adults with a past history of chickenpox, 32 (97%) showed a positive lymphocyte transformation test, but only 11 out of 23 examined (48%) demonstrated mononuclear cell production of specific antibody in vitro; serum antibody was found in 30 (91%) by the ELISA and in 25 out of 26 examined (96%) by the FAMA technique. A high degree of correlation was found between both a positive lymphocyte transformation and the presence of serum antibody and a past history of chickenpox.

摘要

采用酶联免疫吸附测定（ELISA）技术检测了489名实习护士的血清，以确定是否存在水痘-带状疱疹病毒特异性抗体；在446名（91.2%）护士的血清中发现了抗体。在对33名有水痘病史的健康成年人的特异性免疫进行更详细的调查中，32名（97%）的淋巴细胞转化试验呈阳性，但在23名接受检测者中，只有11名（48%）在体外表现出单核细胞产生特异性抗体；通过ELISA法在30名（91%）的血清中发现了抗体，通过荧光抗膜抗体技术（FAMA）在26名接受检测者中的25名（96%）血清中发现了抗体。发现淋巴细胞转化试验阳性、血清抗体的存在与水痘病史之间存在高度相关性。