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[与胸腺瘤相关的获得性低丙种球蛋白血症:古德综合征]

[Acquired hypogammaglobulinemia associated with thymoma: Good syndrome].

作者信息

Aouadi Samira, Ghrairi Najla, Braham Emna, Kaabi Manel, Maâlej Sonia, Elgharbi Leila Douik

机构信息

Service de Pneumologie D, Université de Tunis El Manar, Faculté de Médecine de Tunis, Hôpital Abderrahmen Mami, Ariana, Tunisie.

Laboratoire d'Immunologie Université de Tunis El Manar, Faculté de Médecine de Tunis, Hôpital Abderrahmen Mami, Ariana, Tunisie.

出版信息

Pan Afr Med J. 2017 Nov 22;28:253. doi: 10.11604/pamj.2017.28.253.11352. eCollection 2017.

Abstract

Good syndrome (GS) is defined as the association between thymoma and immune deficiency. It is often complicated by broncho-pulmonary bacterial infections and rhinosinusitis. This disease accounts for only 5% of all parathymic syndromes. These recurrent respiratory infections can cause bronchiectasis associated with Good syndrome. We report the case of a 52-year old woman hospitalized for non resolutive infectious pneumonitis. Chest CT scan showed bronchiectasis associated with thymoma confirmed by biopsy. The discovery of hypogammaglobulinemia allowed the diagnosis of Good syndrome.

摘要

古德综合征(GS)定义为胸腺瘤与免疫缺陷之间的关联。它常并发支气管肺部细菌感染和鼻窦炎。这种疾病仅占所有胸腺旁综合征的5%。这些反复发生的呼吸道感染可导致与古德综合征相关的支气管扩张。我们报告一例52岁女性因难治性感染性肺炎住院的病例。胸部CT扫描显示有与胸腺瘤相关的支气管扩张,活检证实了胸腺瘤。低丙种球蛋白血症的发现使得古德综合征得以诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4119/5989270/453f2b4b0295/PAMJ-28-253-g001.jpg

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