National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA.
Mol Cell. 2018 Jun 7;70(5):761-762. doi: 10.1016/j.molcel.2018.05.025.
Microbes exist in a constant struggle with viruses and have evolved multiple defense mechanisms. Some of these, such as restriction endonucleases and CRISPR-Cas, have revolutionized genome editing methodology. A systematic strategy combining computation and experiment led to discovery of ten new defense systems that remain to be characterized mechanistically.
微生物与病毒之间存在着持续的斗争，并进化出了多种防御机制。其中一些机制，如限制内切酶和 CRISPR-Cas，已经彻底改变了基因组编辑方法。一项结合计算和实验的系统策略，导致发现了十种有待在机制上进行表征的新防御系统。
