Vibholm Helle Annette, Pedersen Jesper, Faltinsen Erlend, Marcussen Michael H, Gluud Christian, Storebø Ole Jakob
Child and Adolescent Psychiatric Department, Region Zealand, Roskilde, Denmark.
Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.
BMC Res Notes. 2018 Jun 8;11(1):366. doi: 10.1186/s13104-018-3478-3.
This study compared the effectiveness of manualised training, executive, attention, and motor skills (TEAMS) training versus standard treatment in preschool children with attention deficit hyperactivity disorder (ADHD). We conducted a randomised parallel group, single-blinded, superiority trial. The primary outcome was ADHD symptoms and the secondary outcome was functionality. Parents and primary school teachers assessed outcomes at pretreatment, posttreatment, and at one, three, and 6 months follow-up.
In total, 67 children (aged 3-6 years) were randomised. In the TEAMS group, 32 out of 33 (97%) participants completed the total 8-week program, compared with only 7 out of 26 (27%) in the control group. The repeated-model analyses showed no significant change between the two interventions for ADHD symptoms and functionality levels over time. The mean difference in ADHD symptoms between TEAMS versus standard treatment at posttreatment was 2.18 points (95% confidence interval - 8.62 to 13.0; trial sequential analysis-adjusted confidence interval - 19.3 to 23.7). Trial registration Clinical Trials identifier: NCT01918436 (Retrospectively registered). Registered on 7 August 2013.
本研究比较了针对注意力缺陷多动障碍(ADHD)学龄前儿童的手动训练、执行、注意力和运动技能(TEAMS)训练与标准治疗的效果。我们进行了一项随机平行组、单盲、优效性试验。主要结局是ADHD症状,次要结局是功能状况。家长和小学教师在治疗前、治疗后以及1个月、3个月和6个月随访时评估结局。
总共67名3至6岁儿童被随机分组。在TEAMS组中,33名参与者中有32名(97%)完成了为期8周的整个项目,而对照组26名参与者中只有7名(27%)完成。重复模型分析显示,随着时间推移,两种干预措施在ADHD症状和功能水平方面没有显著变化。治疗后TEAMS组与标准治疗组在ADHD症状方面的平均差异为2.18分(95%置信区间为-8.62至13.0;试验序贯分析调整后的置信区间为-19.3至23.7)。试验注册临床试验标识符:NCT01918436(回顾性注册)。于2013年8月7日注册。