Department of Medicine, University Health Network, Toronto, ON, Canada.
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Leukemia. 2019 Jan;33(1):15-25. doi: 10.1038/s41375-018-0162-5. Epub 2018 Jun 8.
We previously described impairments in quality of life (QOL) and physical function among acute myeloid leukemia (AML) survivors between diagnosis and 1 year. The aim of the current study is to describe and compare to normative data QOL and physical function recovery over 3 years from diagnosis and treatment with intensive chemotherapy (IC). At assessments done at baseline (pre-IC) and at 11 time points over 3 years, QOL, fatigue, and 3 physical performance measures (PPMs; grip strength, 6-min walk test (6MWT), and timed chair stands) were collected. Long-term recovery was defined by reaching scores within the minimum clinically important difference of normative data. Global QOL recovery was seen in 79% at 1 year, 75% at 2 years, and 86% at 3 years. At 3 years, the QLQ-C30 subscales with the greatest recovery were physical and emotional functioning. For FACT-fatigue, recovery was seen in 68% at 1 year and 77% at 3 years. Recovery on PPMs was poorer on average, with only 17% on the 6MWT and 42% in grip strength returning to normal at 3 years. The vast majority of AML survivors after IC achieve recovery in QOL and fatigue by three years. However, recovery in physical performance remained blunted.
我们之前描述了急性髓系白血病（AML）幸存者在诊断和 1 年内的生活质量（QOL）和身体功能受损。本研究的目的是描述并与诊断和强化化疗（IC）治疗后 3 年的正常数据进行比较，以了解 QOL 和身体功能的恢复情况。在基线（IC 前）评估和 3 年内的 11 个时间点，收集了 QOL、疲劳和 3 项身体表现测量指标（握力、6 分钟步行测试（6MWT）和定时椅子站立）。长期恢复定义为达到正常数据最小临床重要差异范围内的分数。在 1 年、2 年和 3 年时，全球 QOL 恢复率分别为 79%、75%和 86%。在 3 年时，QLQ-C30 子量表中恢复最好的是身体和情绪功能。对于 FACT-疲劳，在 1 年时恢复率为 68%，在 3 年时为 77%。身体表现测量指标的恢复平均较差，只有 6MWT 的 17%和握力的 42%在 3 年内恢复正常。接受 IC 治疗后，绝大多数 AML 幸存者在 3 年内恢复了 QOL 和疲劳。然而，身体表现的恢复仍然滞后。
