RNA Group/Groupe ARN, Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, Québec, J1E 4K8, Canada.
RNA Group/Groupe ARN, Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, Québec, J1E 4K8, Canada.
Biochimie. 2018 Aug;151:115-118. doi: 10.1016/j.biochi.2018.06.002. Epub 2018 Jun 6.
Though RNA G-quadruplexes became a focus of study over a decade ago, the main challenge associated with the identification of new potential G-quadruplexes remains a bottleneck step. It slows the study of these non-canonical structures in nucleic acids, and thus the understanding of their significance. The G4RNA screener is an accurate tool for the prediction of RNA G-quadruplexes but its deployment has brought to light an issue with its accessibility to G-quadruplex experts and biologists. G4RNA screener web server is a platform that provides a much needed interface to manage the input, parameters and result display of the main command-line ready tool. It is accessible at http://scottgroup.med.usherbrooke.ca/G4RNA_screener/.
尽管 RNA 四链体在十多年前就成为了研究的焦点，但与鉴定新的潜在 G-四链体相关的主要挑战仍然是一个瓶颈步骤。这减缓了对这些非 canonical 结构在核酸中的研究，从而也阻碍了对其重要性的理解。G4RNA 筛选器是一种准确预测 RNA G-四链体的工具，但它的使用凸显了 G-四链体专家和生物学家使用它的便捷性存在问题。G4RNA 筛选器网络服务器是一个平台，它提供了一个急需的接口，用于管理主要命令行工具的输入、参数和结果显示。它可以在 http://scottgroup.med.usherbrooke.ca/G4RNA_screener/ 访问。
