• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

常规涂片、液基制片及组织病理学中自然杀伤/T细胞淋巴瘤（鼻型）的诊断细胞形态学比较

Comparison of Diagnostic Cytomorphology of Natural Killer/T-Cell Lymphoma (Nasal Type) in Conventional Smears, Liquid-Based Preparations, and Histopathology.

作者信息

Liu Chih-Yi, Tsai Hui-Chih

机构信息

Division of Pathology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.

College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.

出版信息

Case Rep Pathol. 2018 May 14;2018:6264810. doi: 10.1155/2018/6264810. eCollection 2018.

DOI:10.1155/2018/6264810
PMID:29888018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5977006/
Abstract

Natural killer (NK)/T-cell lymphoma is formally referred to as extranodal NK/T-cell lymphoma, nasal type (ENKTCL), in the 2008 and 2016 World Health Organization (WHO) classifications. NK/T-cell lymphoma, nasal type, is a rare but clinically important lymphoid neoplasm. It is the predominant type of extranodal lymphoma associated with the Epstein-Barr virus (EBV). NK/T-cell lymphoma is marked by a wide cytomorphological spectrum. The cytological findings may be so subtle that NK/T-cell lymphoma could possibly be easily overlooked. Here, we report a case of NK/T-cell lymphoma involving the sinonasal region with lymph node involvement. Fine needle aspiration of the neck lymph node and punch biopsy of the nasal mucosa were performed. The diagnosis of NK/T-cell lymphoma was confirmed based on pathological and immunohistochemical analyses, as well as in situ hybridization for EBV-encoded mRNA (EBER). The present case report underlines the importance of prompt clinicopathological assessment in suspected cases. The comparison of cytomorphologic features of NK/T-cell lymphoma in various specimens is presented.

摘要

在2008年和2016年世界卫生组织（WHO）分类中，自然杀伤（NK）/T细胞淋巴瘤被正式称为鼻型结外NK/T细胞淋巴瘤（ENKTCL）。鼻型NK/T细胞淋巴瘤是一种罕见但临床上重要的淋巴瘤。它是与爱泼斯坦-巴尔病毒（EBV）相关的主要结外淋巴瘤类型。NK/T细胞淋巴瘤具有广泛的细胞形态学谱。细胞学表现可能非常细微，以至于NK/T细胞淋巴瘤很可能容易被忽视。在此，我们报告一例累及鼻窦区域并伴有淋巴结受累的NK/T细胞淋巴瘤病例。对颈部淋巴结进行了细针穿刺抽吸，并对鼻黏膜进行了打孔活检。基于病理和免疫组化分析以及EBV编码mRNA（EBER）的原位杂交，确诊为NK/T细胞淋巴瘤。本病例报告强调了对疑似病例进行及时临床病理评估的重要性。文中还对不同标本中NK/T细胞淋巴瘤的细胞形态学特征进行了比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/9dfe3125a3af/CRIPA2018-6264810.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/e5d9ef957c9a/CRIPA2018-6264810.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/fb4bd0ea6ca8/CRIPA2018-6264810.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/50136d6e5b31/CRIPA2018-6264810.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/b8243e7720bd/CRIPA2018-6264810.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/9dfe3125a3af/CRIPA2018-6264810.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/e5d9ef957c9a/CRIPA2018-6264810.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/fb4bd0ea6ca8/CRIPA2018-6264810.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/50136d6e5b31/CRIPA2018-6264810.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/b8243e7720bd/CRIPA2018-6264810.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb88/5977006/9dfe3125a3af/CRIPA2018-6264810.005.jpg

相似文献

1
Comparison of Diagnostic Cytomorphology of Natural Killer/T-Cell Lymphoma (Nasal Type) in Conventional Smears, Liquid-Based Preparations, and Histopathology.常规涂片、液基制片及组织病理学中自然杀伤/T细胞淋巴瘤（鼻型）的诊断细胞形态学比较
Case Rep Pathol. 2018 May 14;2018:6264810. doi: 10.1155/2018/6264810. eCollection 2018.
2
Nodal presentation of nasal-type NK/T-cell lymphoma. Report of two cases with fine needle aspiration cytology findings.鼻型NK/T细胞淋巴瘤的结内表现。两例细针穿刺细胞学检查结果报告。
Acta Cytol. 2003 Nov-Dec;47(6):1063-8. doi: 10.1159/000326648.
3
Bone marrow that is positive for Epstein-Barr virus encoded RNA-1 by in situ hybridization is related with a poor prognosis in patients with extranodal natural killer/T-cell lymphoma, nasal type.通过原位杂交检测到爱泼斯坦-巴尔病毒编码RNA-1呈阳性的骨髓与鼻型结外自然杀伤/T细胞淋巴瘤患者的不良预后相关。
Haematologica. 2005 Aug;90(8):1063-9.
4
Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology.3例经鼻刷细胞学诊断的鼻型结外NK/T细胞淋巴瘤
Diagn Cytopathol. 2007 Feb;35(2):125-9. doi: 10.1002/dc.20604.
5
Blastic natural killer cell and extranodal natural killer cell-like T-cell lymphoma presenting in the skin: report of six cases from the UK.皮肤原发性母细胞性自然杀伤细胞及结外自然杀伤细胞样T细胞淋巴瘤：来自英国的6例报告
Br J Dermatol. 2003 Mar;148(3):507-15. doi: 10.1046/j.1365-2133.2003.05227.x.
6
Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization.使用爱泼斯坦-巴尔病毒编码的小RNA原位杂交评估爱泼斯坦-巴尔病毒在淋巴结或结外T细胞和NK细胞淋巴瘤病例中的作用。
Pol J Pathol. 2015 Jun;66(2):161-9. doi: 10.5114/pjp.2015.53013.
7
Clinicopathologic, immunophenotypic, and EBER in situ hybridization study of extranodal natural killer/T-cell lymphoma, nasal type in ãmulti-ethnic groups.多民族群体中鼻型结外自然杀伤/T细胞淋巴瘤的临床病理、免疫表型及EBER原位杂交研究
Clin Lab. 2014;60(3):419-25. doi: 10.7754/clin.lab.2013.130236.
8
Fine needle aspiration cytology of CD56-positive natural killer/T-cell lymphoma of soft tissue.软组织CD56阳性自然杀伤/T细胞淋巴瘤的细针穿刺细胞学检查
Cancer. 2002 Dec 25;96(6):344-50. doi: 10.1002/cncr.10885.
9
Series of extranodal natural killer/T-cell lymphoma, nasal type, with periorbital involvement.伴有眶周受累的鼻型结外自然杀伤/T细胞淋巴瘤系列病例。
Orbit. 2014 Aug;33(4):245-51. doi: 10.3109/01676830.2014.902478. Epub 2014 May 15.
10
[Ocular natural killer/T cell lymphoma: a clinicopathologic analysis].[眼自然杀伤/T细胞淋巴瘤：临床病理分析]
Zhonghua Yan Ke Za Zhi. 2019 May 11;55(5):374-380. doi: 10.3760/cma.j.issn.0412-4081.2019.05.012.

引用本文的文献

1
Sinonasal NK/T-cell lymphoma - imaging features overlap with non-neoplastic etiologies.鼻窦NK/T细胞淋巴瘤——影像学特征与非肿瘤性病因重叠。
Emerg Radiol. 2025 May 17. doi: 10.1007/s10140-025-02350-5.

本文引用的文献

1
An algorithmic approach to diagnose haematolymphoid neoplasms in effusion by combining morphology, immunohistochemistry and molecular cytogenetics.一种通过结合形态学、免疫组织化学和分子细胞遗传学来诊断积液中血液淋巴系统肿瘤的算法方法。
Cytopathology. 2018 Feb;29(1):10-21. doi: 10.1111/cyt.12449. Epub 2017 Sep 15.
2
Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.子宫颈鼻型结外NK/T细胞淋巴瘤：一例报告
Diagn Cytopathol. 2016 May;44(5):430-3. doi: 10.1002/dc.23439. Epub 2016 Feb 12.
3
Hematolymphoid lesions of the sinonasal tract.
鼻窦的血液淋巴样病变。
Semin Diagn Pathol. 2016 Mar;33(2):71-80. doi: 10.1053/j.semdp.2015.09.008. Epub 2015 Sep 9.
4
Extranodal natural killer/T-cell lymphoma, nasal type in Taiwan: a relatively higher frequency of T-cell lineage and poor survival for extranasal tumors.台湾的结外自然杀伤/T细胞淋巴瘤，鼻型：T细胞谱系频率相对较高且鼻外肿瘤生存率低。
Hum Pathol. 2015 Feb;46(2):313-21. doi: 10.1016/j.humpath.2014.11.008. Epub 2014 Nov 26.
5
In situ hybridisation for Epstein-Barr virus as a differential diagnostic tool for T- and natural killer/T-cell lymphomas in non-immunocompromised patients.原位杂交检测爱泼斯坦-巴尔病毒作为非免疫功能低下患者T细胞和自然杀伤/T细胞淋巴瘤的鉴别诊断工具
Pathology. 2014 Dec;46(7):581-91. doi: 10.1097/PAT.0000000000000161.
6
Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies.细胞毒性T细胞和NK细胞淋巴瘤：当前的问题与争议
Am J Surg Pathol. 2014 Oct;38(10):e60-71. doi: 10.1097/PAS.0000000000000295.
7
Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer Center.结外 NK/T 细胞淋巴瘤，鼻型：MD 安德森癌症中心 73 例报告。
Am J Surg Pathol. 2013 Jan;37(1):14-23. doi: 10.1097/PAS.0b013e31826731b5.
8
Natural killer cell neoplasm: biology and pathology.自然杀伤细胞肿瘤：生物学和病理学。
Int J Hematol. 2010 Dec;92(5):681-9. doi: 10.1007/s12185-010-0738-y. Epub 2010 Dec 7.
9
Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report.经细针穿刺、脑脊液细胞学及免疫表型分析诊断的肾上腺结外NK/T细胞淋巴瘤：一例报告
Diagn Cytopathol. 2009 Sep;37(9):686-95. doi: 10.1002/dc.21077.
10
Extranodal lymphomas: review of clinicopathologic and cytologic features.结外淋巴瘤：临床病理及细胞学特征综述
Diagn Cytopathol. 2009 Mar;37(3):220-9. doi: 10.1002/dc.21045.