Ersoy B, Aktan B, Kilic K, Sakat M S, Sipal S
Department of Otolaryngology,City Hospital,Mersin,Turkey.
Department of Otolaryngology,Faculty of Medicine,Atatürk University,Erzurum,Turkey.
J Laryngol Otol. 2018 Jul;132(7):579-583. doi: 10.1017/S0022215118000610. Epub 2018 Jun 11.
Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion.
The animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube. Four hours after the end of the administration, histamine solution was injected into the right middle ear.
The lowest neutrophil density value obtained using stereological techniques was in the azithromycin group (0.86 ± 0.25 × 10-5/μm3), while the highest value was observed in the control group (6.68 ± 3.12 × 10-5/μm3). The anti-inflammatory properties of clarithromycin, azithromycin and roxithromycin were similar to one another, but better than that of erythromycin.
The use of macrolide antibiotics is recommended, as they show antibacterial and anti-inflammatory efficacy in otitis media with effusion.
分泌性中耳炎是一种以中耳黏膜炎症为特征的临床表现。本研究调查了红霉素、克拉霉素、阿奇霉素和罗红霉素对组胺诱导的分泌性中耳炎动物模型的治疗效果。
将动物分为五组，分别接受红霉素、克拉霉素、阿奇霉素、罗红霉素或生理盐水。研究组的豚鼠通过胃管接受红霉素（40毫克/千克/天）、克拉霉素（15毫克/千克/天）、阿奇霉素（10毫克/千克/天）或罗红霉素（10毫克/千克/天），持续3天。给药结束4小时后，将组胺溶液注入右中耳。
使用体视学技术获得的最低中性粒细胞密度值出现在阿奇霉素组（0.86±0.25×10⁻⁵/立方微米），而最高值出现在对照组（6.68±3.12×10⁻⁵/立方微米）。克拉霉素、阿奇霉素和罗红霉素的抗炎特性彼此相似，但优于红霉素。
推荐使用大环内酯类抗生素，因为它们在分泌性中耳炎中显示出抗菌和抗炎功效。
