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1
Evidence for a repeating domain in type I restriction enzymes.I型限制酶中重复结构域的证据。
EMBO J. 1985 May;4(5):1351-5. doi: 10.1002/j.1460-2075.1985.tb03784.x.
2
The DNA recognition subunit of the type IB restriction-modification enzyme EcoAI tolerates circular permutions of its polypeptide chain.I型B类限制修饰酶EcoAI的DNA识别亚基能够耐受其多肽链的环形排列。
J Mol Biol. 1998 Dec 11;284(4):937-48. doi: 10.1006/jmbi.1998.2250.
3
On the structure and operation of type I DNA restriction enzymes.关于I型DNA限制酶的结构与操作
J Mol Biol. 1999 Jul 9;290(2):565-79. doi: 10.1006/jmbi.1999.2908.
4
Target recognition by EcoKI: the recognition domain is robust and restriction-deficiency commonly results from the proteolytic control of enzyme activity.EcoKI的靶标识别：识别结构域具有稳健性，限制缺陷通常源于酶活性的蛋白水解调控。
J Mol Biol. 2001 Mar 30;307(3):951-63. doi: 10.1006/jmbi.2001.4543.
5
Protein-DNA recognition.蛋白质-脱氧核糖核酸识别
Annu Rev Biochem. 1984;53:293-321. doi: 10.1146/annurev.bi.53.070184.001453.
6
A mutational analysis of the PD...D/EXK motif suggests that McrC harbors the catalytic center for DNA cleavage by the GTP-dependent restriction enzyme McrBC from Escherichia coli.对PD...D/EXK基序的突变分析表明，McrC含有来自大肠杆菌的GTP依赖性限制酶McrBC切割DNA的催化中心。
Biochemistry. 2002 Apr 23;41(16):5236-44. doi: 10.1021/bi0156862.
7
Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.2.9埃分辨率下分解代谢物基因激活蛋白的结构。氨基酸序列的整合及与环磷酸腺苷的相互作用。
J Biol Chem. 1982 Aug 25;257(16):9518-24.
8
Two DNA recognition domains of the specificity polypeptides of a family of type I restriction enzymes.I型限制酶家族特异性多肽的两个DNA识别结构域。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9368-72. doi: 10.1073/pnas.83.24.9368.
9
Hin4II, a new prototype restriction endonuclease from Haemophilus influenzae RFL4: discovery, cloning and expression in Escherichia coli.Hin4II，一种来自流感嗜血杆菌RFL4的新型限制性内切核酸酶原型：发现、克隆及在大肠杆菌中的表达
J Biotechnol. 2006 May 29;123(3):288-96. doi: 10.1016/j.jbiotec.2005.12.016. Epub 2006 Jan 26.
10
The nucleotide sequence recognised by the Escherichia coli D type I restriction and modification enzyme.大肠杆菌I型D类限制与修饰酶识别的核苷酸序列。
Nucleic Acids Res. 1985 Jan 25;13(2):389-99. doi: 10.1093/nar/13.2.389.

引用本文的文献

1
Deletion of one nucleotide within the homonucleotide tract present in the hsdS gene alters the DNA sequence specificity of type I restriction-modification system NgoAV.在 hsdS 基因中存在的同核苷酸序列内缺失一个核苷酸会改变 NgoAV 型 I 限制修饰系统的 DNA 序列特异性。
J Bacteriol. 2011 Dec;193(23):6750-9. doi: 10.1128/JB.05672-11. Epub 2011 Oct 7.
2
EcoR124I: from plasmid-encoded restriction-modification system to nanodevice.EcoR124I：从质粒编码的限制修饰系统到纳米器件
Microbiol Mol Biol Rev. 2008 Jun;72(2):365-77, table of contents. doi: 10.1128/MMBR.00043-07.
3
Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux.接合质粒pIP1206的序列，其通过16S rRNA甲基化介导对氨基糖苷类的抗性，并通过外排介导对亲水性氟喹诺酮类的抗性。
Antimicrob Agents Chemother. 2008 Jul;52(7):2581-92. doi: 10.1128/AAC.01540-07. Epub 2008 May 5.
4
Nucleoside triphosphate-dependent restriction enzymes.核苷三磷酸依赖性限制酶
Nucleic Acids Res. 2001 Sep 15;29(18):3728-41. doi: 10.1093/nar/29.18.3728.
5
Type I restriction systems: sophisticated molecular machines (a legacy of Bertani and Weigle).I型限制系统：复杂的分子机器（贝尔塔尼和魏格尔的遗产）
Microbiol Mol Biol Rev. 2000 Jun;64(2):412-34. doi: 10.1128/MMBR.64.2.412-434.2000.
6
A prediction of the amino acids and structures involved in DNA recognition by type I DNA restriction and modification enzymes.I型DNA限制与修饰酶识别DNA所涉及的氨基酸及结构预测。
Nucleic Acids Res. 1997 Sep 1;25(17):3408-14. doi: 10.1093/nar/25.17.3408.
7
Generation of new DNA binding specificity by truncation of the type IC EcoDXXI hsdS gene.通过截短I型C类EcoDXXI hsdS基因产生新的DNA结合特异性。
EMBO J. 1996 Sep 2;15(17):4775-83.
8
Macroevolution by transposition: drastic modification of DNA recognition by a type I restriction enzyme following Tn5 transposition.转座介导的宏观进化：Tn5转座后I型限制酶对DNA识别的剧烈改变。
EMBO J. 1993 Dec;12(12):4585-91. doi: 10.1002/j.1460-2075.1993.tb06147.x.
9
A motif conserved among the type I restriction-modification enzymes and antirestriction proteins: a possible basis for mechanism of action of plasmid-encoded antirestriction functions.I型限制修饰酶和抗限制蛋白中保守的基序：质粒编码抗限制功能作用机制的可能基础。
Nucleic Acids Res. 1995 Mar 11;23(5):785-7. doi: 10.1093/nar/23.5.785.
10
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.鸡雌激素受体序列：与v-erbA以及人雌激素和糖皮质激素受体的同源性。
EMBO J. 1986 May;5(5):891-7. doi: 10.1002/j.1460-2075.1986.tb04300.x.

本文引用的文献

1
Homology in protein sequences expressed by correlation coefficients.通过相关系数表示的蛋白质序列中的同源性。
J Theor Biol. 1981 Jul 21;91(2):347-61. doi: 10.1016/0022-5193(81)90237-x.
2
Amino acid distribution in protein secondary structures.蛋白质二级结构中的氨基酸分布。
Int J Pept Protein Res. 1982 Apr;19(4):380-93. doi: 10.1111/j.1399-3011.1982.tb02619.x.
3
An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences.一个用于比较和比对核酸及氨基酸序列的交互式图形程序。
Nucleic Acids Res. 1982 May 11;10(9):2951-61. doi: 10.1093/nar/10.9.2951.
4
The operator-binding domain of lambda repressor: structure and DNA recognition.λ阻遏蛋白的操纵子结合结构域：结构与DNA识别
Nature. 1982 Jul 29;298(5873):443-7. doi: 10.1038/298443a0.
5
Homology among DNA-binding proteins suggests use of a conserved super-secondary structure.DNA结合蛋白之间的同源性表明存在保守的超二级结构。
Nature. 1982 Jul 29;298(5873):447-51. doi: 10.1038/298447a0.
6
Structural homology of lens crystallins. A method to detect protein structural homology from primary sequences.晶状体晶状体蛋白的结构同源性。一种从一级序列检测蛋白质结构同源性的方法。
Eur J Biochem. 1983 Mar 1;131(1):143-8. doi: 10.1111/j.1432-1033.1983.tb07241.x.
7
Prediction of secondary structural elements in glycerol-3-phosphate dehydrogenase by comparison with other dehydrogenases.通过与其他脱氢酶比较预测3-磷酸甘油脱氢酶的二级结构元件
Eur J Biochem. 1980 Aug;109(2):325-30. doi: 10.1111/j.1432-1033.1980.tb04798.x.
8
A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.磷酸核糖转移酶三级结构中可能存在的核苷酸结合结构域。
J Biol Chem. 1983 May 25;258(10):6450-7.
9
Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically.位点特异性重组蛋白γδ解离酶的切割：两个片段中较小的片段特异性结合DNA。
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2001-5. doi: 10.1073/pnas.81.7.2001.
10
Sequence diversity among related genes for recognition of specific targets in DNA molecules.用于识别DNA分子中特定靶标的相关基因间的序列多样性。
J Mol Biol. 1983 May 5;166(1):1-19. doi: 10.1016/s0022-2836(83)80047-3.

I型限制酶中重复结构域的证据。

Evidence for a repeating domain in type I restriction enzymes.

作者信息

Argos P

出版信息

EMBO J. 1985 May;4(5):1351-5. doi: 10.1002/j.1460-2075.1985.tb03784.x.

DOI:10.1002/j.1460-2075.1985.tb03784.x
PMID:2988943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC554348/
Abstract

The primary structures of the recognition subunit (hsdS) in type I restriction enzymes from three isolates of Escherichia coli were compared and aligned by use of amino acid physical properties. A repeating domain was found in each of the subunits suggesting a pseudo-dimeric structure. Secondary structure predictions delineated two helical regions in each domain which suggested that the recognition subunits may act in a fashion similar to that proposed for repressor and activator molecules; namely, interaction with double-stranded DNA through helices and in two successive major grooves on the same DNA side. One helical motif could provide the specific recognition site and the other, the restriction site.

摘要

利用氨基酸物理性质，对来自三株大肠杆菌的I型限制酶识别亚基（hsdS）的一级结构进行了比较和比对。在每个亚基中都发现了一个重复结构域，提示其具有假二聚体结构。二级结构预测在每个结构域中勾勒出两个螺旋区域，这表明识别亚基的作用方式可能与阻遏物和激活分子类似；即通过螺旋与双链DNA相互作用，并在同一DNA链的两个连续大沟中进行。一个螺旋基序可提供特异性识别位点，另一个则提供限制位点。