Pauwels E K, Bolk J H, Heslinga J M
Eur J Nucl Med. 1985;10(9-10):403-5. doi: 10.1007/BF00256579.
Ten patients with biochemical and clinical evidence of primary hyperparathyroidism were studied scintigraphically using a double-radionuclide subtraction technique. Preoperative imaging was performed with Sodium pertechnetate Tc 99m and thallium chloride Tl 201 using a gamma camera with a pinhole collimator. The data were stored in a matrix of 64 X 64. The avidity of 201Tl for nodules of the parathyroid gland was demonstrated on analogue and digital images both with and without the subtraction of thyroid tissue. In our ten patients, this technique detected nine out of ten histologically proven adenomas, and missed a relatively small lesion embedded within the thyroid of one patient. This method may have considerable advantages over non-specific or invasive radiodiagnostic methods, and may facilitate the diagnosis and planning of the surgical approach in cases of primary hyperparathyroidism.
采用双放射性核素减影技术对10例有原发性甲状旁腺功能亢进生化及临床证据的患者进行了闪烁扫描研究。术前使用锝[99mTc]高锝酸钠和氯化铊[201Tl]，通过带有针孔准直器的γ相机进行成像。数据存储在64×64的矩阵中。在有或没有减去甲状腺组织的模拟图像和数字图像上，均显示了201Tl对甲状旁腺结节的摄取。在我们的10例患者中，该技术检测出10例经组织学证实的腺瘤中的9例，遗漏了1例位于甲状腺内的相对较小的病变。该方法可能比非特异性或侵入性放射诊断方法具有相当大的优势，并且可能有助于原发性甲状旁腺功能亢进病例的诊断和手术入路规划。
