Cann C E, Prussin S G
J Nucl Med. 1980 May;21(5):471-4.
Aluminum has been found to localize in parathyroid adenomas, but it has no isotopes suitable for imaging. Chemical analogs of aluminum were therefore evaluated as potential parathyroid seekers. Uptakes of gallium-67, scandium-46 and lutetium-177 were measured in rat parathyroid, thyroid, cervical muscle, and whole blood, over the time period 30 min to 8 days. Both differential and absolute uptakes of Ga-67 and Sc-46 in the parathyroids are greater than that reported for Se-75 selenomethionine. Uptake of Ga-67 is about 2% of the injected dose per gram of parathyroid tissue at 3-4 days, with a parathyroid-to-thyroid uptake ratio of about 6. Studies indicate possible imaging of adenomas at least as small as those now detected only with invasive methods.
已发现铝在甲状旁腺腺瘤中聚集，但它没有适合成像的同位素。因此，对铝的化学类似物作为潜在的甲状旁腺探寻剂进行了评估。在30分钟至8天的时间段内，测量了大鼠甲状旁腺、甲状腺、颈部肌肉和全血中镓 - 67、钪 - 46和镥 - 177的摄取量。甲状旁腺中镓 - 67和钪 - 46的差异摄取量和绝对摄取量均高于报道的硒 - 75硒代蛋氨酸的摄取量。在3 - 4天时，每克甲状旁腺组织中镓 - 67的摄取量约为注射剂量的2%，甲状旁腺与甲状腺的摄取比约为6。研究表明，至少与目前仅通过侵入性方法检测到的腺瘤一样小的腺瘤有可能实现成像。
