Rhee Ye-Young, Jung Hong Kyu, Kim Se Hoon, Kim Soo Hee
Pathology Center, Seegene Medical Foundation, Seoul, Korea.
Department of Surgery and Health Care Center, Seran Hospital, Seoul, Korea.
J Pathol Transl Med. 2018 Jul;52(4):252-256. doi: 10.4132/jptm.2018.04.28. Epub 2018 Jun 11.
Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment. Here, we report a case of HTT with novel cytologic features in CellPrep liquid based cytology that was diagnosed as suspicious for papillary carcinoma by FNA and finally diagnosed as HTT in the surgical specimen.
透明变梁状肿瘤（HTT）是一种罕见的甲状腺肿瘤，恶性潜能低至极低。在细针穿刺（FNA）细胞学检查中，HTT常因具有核沟和核内假包涵体等重叠的细胞学特征而被误诊为其他甲状腺肿瘤，包括乳头状甲状腺癌（PTC）和髓样甲状腺癌（MTC）。尽管细胞病理学家无法通过FNA细胞学检查明确诊断HTT，但怀疑HTT对于避免将其误诊为PTC或MTC以及避免不必要的积极治疗是必要的。在此，我们报告一例HTT病例，其在CellPrep液基细胞学检查中具有新的细胞学特征，FNA检查诊断为乳头状癌可疑，最终手术标本诊断为HTT。
