Department of Surgery and Medical Surgical Specialties, Medicine and Dentistry School, Universidade de Santiago de Compostela, 15782 Spain.
Liquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago de Compostela (IDIS), CIBERONC, 15706 Santiago de Compostela, Spain.
Int J Mol Sci. 2018 Jun 8;19(6):1704. doi: 10.3390/ijms19061704.
Oral cancer is one of the most prevalent forms of cancer worldwide. Carcinogenesis is a complex process, in which heterogeneity plays an important role in the development and progression of the disease. This review provides an overview of the current biological and clinical significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and exosomes for diagnosis and prognosis of oral cancer. We highlight the importance of liquid biopsy—using blood and saliva—which represents a potential alternative to solid biopsy for diagnosis and prognosis. Moreover, liquid biomarkers allow for the real-time monitoring of tumour evolution and therapeutic responses, initiating the era of personalized medicine. However, in oral cancer, the impact of liquid biopsies in clinical settings is still limited, requiring further studies to discover the best scenario for its clinical use.
口腔癌是全球最常见的癌症之一。癌症发生是一个复杂的过程，其中异质性在疾病的发展和进展中起着重要作用。这篇综述概述了循环肿瘤细胞（CTC）、循环肿瘤 DNA（ctDNA）和外泌体在口腔癌诊断和预后中的当前生物学和临床意义。我们强调了液体活检的重要性——使用血液和唾液——这代表了替代实体活组织检查进行诊断和预后的一种潜在方法。此外，液体生物标志物可以实时监测肿瘤的演变和治疗反应，开创了个性化医疗的时代。然而，在口腔癌中，液体活检在临床环境中的影响仍然有限，需要进一步的研究来发现其临床应用的最佳方案。
