基因组学在多发性骨髓瘤中的潜在临床应用。
Potential Clinical Application of Genomics in Multiple Myeloma.
机构信息
Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, 1E Kent Ridge Road, Singapore 119228, Singapore.
Department of Laboratory Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
出版信息
Int J Mol Sci. 2018 Jun 10;19(6):1721. doi: 10.3390/ijms19061721.
Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma.
多发性骨髓瘤是一种具有不同特征的异质性疾病，遗传异常在这种异质性中起着重要作用。研究表明，这些遗传异常对预后和反应评估至关重要；最近的研究重点是它们可能的治疗意义。尽管有许多新的研究发表，但将这些结果纳入临床实践的最佳方法仍不清楚。在这篇综述论文中，我们描述了现有的不同基因组技术，包括最新进展，并讨论了基因组学在多发性骨髓瘤中的潜在临床应用。
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