Aristizabal Arboleda Paola, Sánchez-Romero Celeste, de Almeida Oslei Paes, Flores Alvarado Sergio A, Martínez Pedraza Ricardo
1 Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
2 Instituto Mexicano del Seguro Social, Saltillo, Coahuila, México.
Int J Surg Pathol. 2018 Dec;26(8):758-765. doi: 10.1177/1066896918777639. Epub 2018 Jun 11.
Calcifying odontogenic cyst (COC) is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. COCs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst (DC). In this article, we describe a case of COC associated with DC in a 15-year-old girl, who presented with a swelling on the right middle third of the face, producing facial asymmetry. Panoramic radiography showed a well-circumscribed, corticated, and unilocular radiolucency at the level of the right maxillary sinus, involving 2 unerupted premolars. The lesion was enucleated and histologically revealed a COC associated with DC, which presented mucous metaplasia. Immunohistochemical reactions were performed to better illustrate this rare synchronous occurrence of COC and DC, showing positivity for CK5, CK14, CK19, and p63 in both lesions. CK18 was negative in COC, and Bcl-2 was negative in DC. Periodic acid Schiff highlighted the mucous cells in the DC lining.
钙化牙源性囊肿（COC）是一种罕见的牙源性囊肿，其成釉细胞上皮衬里含有成簇的影细胞。COC已被描述与多种牙源性肿瘤相关，更常见的是牙瘤，很少与含牙囊肿（DC）相关。在本文中，我们描述了一例15岁女孩的COC与DC相关病例，该女孩右侧面部中三分之一处肿胀，导致面部不对称。全景X线片显示右上颌窦水平有一个边界清晰、有皮质、单房的透射区，累及2颗未萌出的前磨牙。病变被摘除，组织学显示为与DC相关的COC，表现为黏液化生。进行免疫组织化学反应以更好地说明COC和DC这种罕见的同步发生情况，显示两个病变中CK5、CK14、CK19和p63均呈阳性。CK18在COC中为阴性，Bcl-2在DC中为阴性。过碘酸希夫染色突出了DC衬里中的黏液细胞。
