Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.
Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas.
Am J Med Sci. 2018 Jun;355(6):573-580. doi: 10.1016/j.amjms.2018.03.001. Epub 2018 Mar 5.
Joint hypermobility is a common, primarily benign finding in the general population. However, in a subset of individuals joint hypermobility causes a range of clinical problems mainly affecting the musculoskeletal system and, to a lesser extent, extra-articular disorders. Joint hypermobility often appears as a familial trait and is shared by several inherited connective tissue disorders, including the hypermobility subtype of Ehlers-Danlos syndrome (hEDS) and benign joint hypermobility syndrome (BJHS/JHS). Although joint hypermobility has primarily been thought of as a rheumatological disorder, increasing evidence shows significant associations between both hEDS and BJHS with specific extra-articular disorders. To date, the strongest associations of these 2 conditions are with anxiety disorders, orthostatic tachycardia, various functional gastrointestinal (GI) disorders and pelvic and bladder dysfunction. This review article focuses on GI disorders associated with both hEDS and BJHS. The aim of this review is to evaluate existing research and literature regarding associations between JHS (hEDS/BJHS) and GI disorders. Our goal is to raise awareness of BJHS/JHS and hEDS as an explanation for chronic unexplained symptoms and functional GI disorders as well as to review the current standard tests available for proper evaluation of GI symptoms in these patients.
关节过度活动是一种常见的、主要为良性的现象，在普通人群中较为普遍。然而，在一小部分人群中，关节过度活动会导致一系列的临床问题，主要影响肌肉骨骼系统，在较小程度上也会影响关节外的疾病。关节过度活动通常表现为家族性特征，与几种遗传性结缔组织疾病有关，包括埃勒斯-当洛斯综合征（hEDS）的过度活动型和良性关节过度活动综合征（BJHS/JHS）。尽管关节过度活动主要被认为是一种风湿病，但越来越多的证据表明，hEDS 和 BJHS 与特定的关节外疾病之间存在显著关联。迄今为止，这两种疾病与焦虑症、直立性心动过速、各种功能性胃肠（GI）疾病以及骨盆和膀胱功能障碍的关联最为密切。本文主要关注与 hEDS 和 BJHS 相关的 GI 疾病。本文的目的是评估有关 JHS（hEDS/BJHS）和 GI 疾病之间关联的现有研究和文献。我们的目标是提高对 BJHS/JHS 和 hEDS 的认识，将其作为慢性不明原因症状和功能性 GI 疾病的解释，并回顾目前可用于这些患者胃肠道症状评估的标准测试。
