亚胺培南联合阿米卡星或多粘菌素B对耐碳青霉烯类铜绿假单胞菌分离株的体外抗菌活性
In vitro antimicrobial activity of imipenem plus amikacin or polymyxin B against carbapenem-resistant Pseudomonas aeruginosa isolates.
作者信息
Wilhelm Camila M, Nunes Luciana de S, Martins Andreza F, Barth Afonso L
机构信息
Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil; Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, Brazil.
出版信息
Diagn Microbiol Infect Dis. 2018 Oct;92(2):152-154. doi: 10.1016/j.diagmicrobio.2018.05.004. Epub 2018 May 12.
The aim of this study was to evaluate the antimicrobial activity of imipenem plus amikacin or polymyxin B against six carbapenem-resistant P. aeruginosa by time-kill assay. Synergism was observed in two isolates for combinations with amikacin. For combinations with polymyxin B, synergism and antagonism also occurred in two isolates.
本研究的目的是通过时间杀菌试验评估亚胺培南联合阿米卡星或多粘菌素B对6株耐碳青霉烯类铜绿假单胞菌的抗菌活性。在与阿米卡星联合使用时，在2株分离株中观察到协同作用。在与多粘菌素B联合使用时，2株分离株中也出现了协同作用和拮抗作用。
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