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西班牙医院常规临床实践中中度至重度银屑病的管理

Management of Moderate to Severe Psoriasis in Routine Clinical Practice in Spanish Hospitals.

作者信息

López-Estebaranz J L, de la Cueva-Dobao P, de la Torre Fraga C, Galán Gutiérrez M, González Guerra E, Mollet Sánchez J, Belinchón Romero I

机构信息

Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

Servicio de Dermatología, Hospital Universitario Infanta Leonor, Madrid, España.

出版信息

Actas Dermosifiliogr (Engl Ed). 2018 Sep;109(7):631-642. doi: 10.1016/j.ad.2018.02.015. Epub 2018 Jun 8.

Abstract

BACKGROUND

There is currently little information available on the management of patients with psoriasis in the daily clinical practice of dermatologists in Spain.

OBJECTIVE

The aim of this study was to survey a group of Spanish dermatologists with particular expertise in the management of psoriasis to determine their opinions on the protocols used in routine clinical practice.

MATERIAL AND METHODS

A cross-sectional study based on an online survey about the management of psoriasis sent to 75 dermatologists. The survey, which was specifically designed for the study, included 12questions on different aspects of clinical practice in the treatment of moderate to severe psoriasis.

RESULTS

The response rate was 96% (n=72). Biologics were the most widely used monotherapy option. In total, 64.3% of respondents reported that their patients used conventional systemic therapies for 1 to 2years before switching to a biologic drug and that the main reason for the switch was unstable control of disease activity. Overall, 85.7% assigned a "high" or "very high" importance to the use of a Psoriasis Area Severity Index score of <3 as a treatment goal. The drugs of choice among the respondents were etanercept for pediatric patients (78.6%), adalimumab and etanercept for patients with psoriatic arthritis (64.3%), and ustekinumab in patients frequently away from home (78.6%) and patients with a history of multiple sclerosis, demyelinating diseases (64.3%), or poor adherence to treatment (71.4%).

CONCLUSION

This study provides a unique overview of the opinions of a representative sample of expert dermatologists on the current use of biologics for the treatment of psoriasis in Spain.

摘要

背景

目前在西班牙皮肤科医生的日常临床实践中,关于银屑病患者管理的信息很少。

目的

本研究的目的是调查一组在银屑病管理方面具有特殊专业知识的西班牙皮肤科医生,以确定他们对常规临床实践中使用的方案的看法。

材料和方法

基于一项关于银屑病管理的在线调查开展的横断面研究,该调查发送给了75名皮肤科医生。该调查是专门为该研究设计的,包括12个关于中度至重度银屑病治疗临床实践不同方面的问题。

结果

回复率为96%(n = 72)。生物制剂是使用最广泛的单一疗法选择。总体而言,64.3%的受访者报告称,他们的患者在改用生物药物之前使用传统全身疗法1至2年,而换药的主要原因是疾病活动控制不稳定。总体而言,85.7%的受访者认为将银屑病面积和严重程度指数评分<3作为治疗目标具有“高”或“非常高”的重要性。受访者中,儿科患者的首选药物是依那西普(78.6%),银屑病关节炎患者的首选药物是阿达木单抗和依那西普(64.3%),经常离家的患者以及有多发性硬化症、脱髓鞘疾病病史或治疗依从性差的患者的首选药物是乌司奴单抗(78.6%)和(64.3%)。

结论

本研究提供了一个独特的概述,即西班牙专家皮肤科医生代表性样本对目前使用生物制剂治疗银屑病的看法。

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