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具有早幼粒细胞特征的急性髓系白血病病例，其特征为表达一种新型融合基因。

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel - fusion.

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, MO.

McDonnell Genome Institute, Washington University, St. Louis, MO; and.

出版信息

Blood Adv. 2018 Jun 12;2(11):1295-1299. doi: 10.1182/bloodadvances.2017014183.

DOI:10.1182/bloodadvances.2017014183
PMID:29891591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5998929/
Abstract

Novel fusion in an AML case with promyelocytic features and no evidence of - or X- fusion. Gene fusions involving can initiate AML with promyelocytic morphological features.

摘要

在一个具有早幼粒细胞特征且无证据或 X-融合的 AML 病例中发现新型融合。涉及 的基因融合可引发具有早幼粒细胞形态特征的 AML。

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本文引用的文献

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BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas.骨形态发生蛋白2/骨形态发生蛋白受体1A与去分化脂肪肉瘤的肿瘤进展相关。
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Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms.三名嗜酸性粒细胞增多相关骨髓增殖性肿瘤患者中PDGFRB与MPRIP、CPSF6和GOLGB1的融合
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Retinoic acid receptors: from molecular mechanisms to cancer therapy.维甲酸受体：从分子机制到癌症治疗。
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Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.维甲酸/类视黄醇信号在介导 NUP98-RARG 白血病的转化和治疗反应中的关键作用。
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