Gheissari Alaleh, Meamar Rokhsareh, Abedini Amin, Roomizadeh Peyman, Shafiei Mohammad, Samaninobandegani Zahra, Tabrizi Zhale, Mahmoudi Farhad, Merrikhi Alireza, Najafi Tavana Esfandiar
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Kidney Dis. 2018 May;12(3):169-177.
Cardiovascular disease (CVD) is the main cause of death in children with end-stage renal disease (ESRD). Matrix metalloproteinases (MMP-2 and MMP-9) are members of endopeptidases which contribute to CVD. The aim of this study was to evaluate the association of MMP-2 and MMP-9 with markers of endothelial dysfunction, soluble E-selectin and brachial flow-mediated dilatation; several biochemical risk factors of CVD; and thrombotic incidents in children with ESRD.
Thirty-one children with ESRD and 18 healthy age- and sex-adjusted controls underwent measurement of serum levels of MMP-2, MMP-9, soluble E-selectin, phosphorus, calcium, parathyroid hormone, lipid profile, thrombotic factors, and albumin. Flow-mediated dilatation was measured in both groups by Doppler ultrasonography. Thrombotic events were assessed in patients with ESRD.
Matrix metalloproteinase-2 positively correlated with systolic and diastolic blood pressure, soluble E-selectin, creatinine, cholesterol, triglyceride, low-density lipoprotein cholesterol, phosphorus, and parathyroid hormone and negatively correlated with body mass index, hemoglobin, high-density lipoprotein cholesterol, and flow-mediated dilatation, while MMP-9 correlated with soluble E-selectin, phosphorus, parathyroid hormone, and albumin and negatively correlated with body mass index and hemoglobin. Six patients (19.3%) had thrombotic incidents. There was no significant difference between the levels of MMP-2 and MMP-9 in the children with and without thrombotic events.
This study determined the associations of MMP-2 and MMP-9 with markers of endothelial dysfunction and several traditional and uremia related CVD risk factors in children with ESRD. No associations were found between these two MMPs and thrombotic events.
心血管疾病（CVD）是终末期肾病（ESRD）患儿的主要死因。基质金属蛋白酶（MMP - 2和MMP - 9）是内肽酶的成员，与心血管疾病有关。本研究的目的是评估MMP - 2和MMP - 9与内皮功能障碍标志物、可溶性E - 选择素和肱动脉血流介导的扩张；几种心血管疾病的生化危险因素；以及ESRD患儿血栓形成事件之间的关联。
31例ESRD患儿和18例年龄及性别匹配的健康对照者接受了血清MMP - 2、MMP - 9、可溶性E - 选择素、磷、钙、甲状旁腺激素、血脂谱、血栓形成因子和白蛋白水平的检测。两组均通过多普勒超声测量血流介导的扩张。对ESRD患者的血栓形成事件进行评估。
基质金属蛋白酶 - 2与收缩压和舒张压、可溶性E - 选择素、肌酐、胆固醇、甘油三酯、低密度脂蛋白胆固醇、磷和甲状旁腺激素呈正相关，与体重指数、血红蛋白、高密度脂蛋白胆固醇和血流介导的扩张呈负相关，而MMP - 9与可溶性E - 选择素、磷、甲状旁腺激素和白蛋白相关，与体重指数和血红蛋白呈负相关。6例患者（19.3%）发生了血栓形成事件。有血栓形成事件和无血栓形成事件的患儿之间MMP - 2和MMP - 9水平无显著差异。
本研究确定了ESRD患儿中MMP - 2和MMP - 9与内皮功能障碍标志物以及几种传统和尿毒症相关心血管疾病危险因素之间的关联。未发现这两种基质金属蛋白酶与血栓形成事件之间存在关联。
