降钙素原在脑膜炎诊断中的作用：文献综述
The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review.
作者信息
Velissaris Dimitrios, Pintea Martina, Pantzaris Nikolaos, Spatha Eirini, Karamouzos Vassilios, Pierrakos Charalampos, Karanikolas Menelaos
机构信息
Department of Medicine, University of Patras, 26504 Patras, Greece.
University of Medicine and Pharmacy, 400337 Cluj-Napoca, România.
出版信息
J Clin Med. 2018 Jun 11;7(6):148. doi: 10.3390/jcm7060148.
Abstract
OBJECTIVE
To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis.
METHODS
We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a known or suspected central nervous system infection. We also reviewed the bibliographies of all identified manuscripts in an attempt to identify additional relevant references.
RESULTS
A significant body of evidence suggests that serum procalcitonin has a promising role and can be a useful biomarker in the assessment of patients with meningitis.
CONCLUSIONS
Our literature review suggests that data on the role of Cerebrospinal Fluid (CSF) procalcitonin are limited, whereas serum procalcitonin (S⁻PCT) is probably a useful tool in the evaluation of patients with a known or suspected central nervous system infection and can help distinguish between bacterial and viral meningitis.
摘要
目的
回顾目前已发表的关于降钙素原在成年脑膜炎患者中作为诊断和预后标志物应用的文献。
方法
我们在PubMed上进行检索，以识别所有关于血清降钙素原在已知或疑似中枢神经系统感染患者中的诊断和预后价值的相关出版物。我们还查阅了所有已识别手稿的参考文献，试图找到更多相关参考文献。
结果
大量证据表明，血清降钙素原具有重要作用，可作为评估脑膜炎患者的有用生物标志物。
结论
我们的文献综述表明，关于脑脊液降钙素原作用的数据有限，而血清降钙素原可能是评估已知或疑似中枢神经系统感染患者的有用工具，有助于区分细菌性和病毒性脑膜炎。
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