Boehm Cheyanne, Doig Christopher, Chen Justin Z, Sligl Wendy I, Bagshaw Sean M, Conly John
Department of Pharmacy Services, Alberta Health Services, Calgary, Alberta, Canada.
Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada.
J Assoc Med Microbiol Infect Dis Can. 2021 Sep 30;6(3):229-235. doi: 10.3138/jammi-2020-0046. eCollection 2021 Sep.
West Nile virus neuroinvasive disease (WNV-NID) is challenging to diagnose. Procalcitonin (PCT) is a useful diagnostic test to identify bacterial infections. We present four cases of WNV-NID with serum PCT measurements.
Daily (days 1-7) serum PCT (bioMérieux) was examined for critically ill patients with sepsis enrolled in a provincial sepsis study. Patients with identified WNV-NID are descriptively analyzed in this case series. PCT values of ≥0.5 ng/mL were suggestive of bacterial infection.
Four patients with WNV-NID were identified. Those with viral infections alone had consistently low PCT values ranging from 0.09 ng/mL to 0.34 ng/mL. Those with documented bacterial co-infections had initially elevated PCT levels that decreased by more than 50% with antimicrobial therapy.
These cases are the first to report serial PCT measurements in confirmed cases of WNV-NID and support a low serum PCT in WNV-NID.
西尼罗河病毒神经侵袭性疾病（WNV-NID）的诊断具有挑战性。降钙素原（PCT）是一种用于识别细菌感染的有用诊断测试。我们报告了4例进行血清PCT检测的WNV-NID病例。
在一项省级脓毒症研究中，对患有脓毒症的重症患者每日（第1 - 7天）检测血清PCT（生物梅里埃公司产品）。在此病例系列中对确诊为WNV-NID的患者进行描述性分析。PCT值≥0.5 ng/mL提示细菌感染。
确诊4例WNV-NID患者。单纯病毒感染患者的PCT值始终较低，范围为0.09 ng/mL至0.34 ng/mL。有记录的合并细菌感染患者最初PCT水平升高，经抗菌治疗后下降超过50%。
这些病例是首次报告确诊WNV-NID病例的连续PCT测量结果，支持WNV-NID患者血清PCT水平较低的观点。
