Marone G, Petracca R, Vigorita S
Int Arch Allergy Appl Immunol. 1985;77(1-2):259-63. doi: 10.1159/000233805.
Adenosine is a natural nucleoside that plays a physiological role in the modulation of human inflammatory cells. We have investigated the presence of adenosine A2/Ra and A1/Ri receptors and of the P-site on human inflammatory cells. Human B and T(OKT4+ and OKT8+) lymphocytes, polymorphonuclear leucocytes, monocytes, basophils and platelets possess a membrane adenosine A2/Ra receptor. The activation of adenosine A2/Ra receptor increases the intracellular level of cyclic AMP in these cells. Human lymphocytes and neutrophils possess also an inhibitory adenosine A1/Ri receptor and a P-site whose activation inhibits the effect of many adenylate cyclase agonists including isoproterenol, PGE1, histamine, adenosine, cholera toxin and forskolin.
腺苷是一种天然核苷，在调节人体炎症细胞方面发挥生理作用。我们研究了人体炎症细胞上腺苷A2/Ra和A1/Ri受体以及P位点的存在情况。人B淋巴细胞和T（OKT4+和OKT8+）淋巴细胞、多形核白细胞、单核细胞、嗜碱性粒细胞和血小板都拥有膜腺苷A2/Ra受体。腺苷A2/Ra受体的激活会增加这些细胞内的环磷酸腺苷水平。人淋巴细胞和中性粒细胞还拥有抑制性腺苷A1/Ri受体和一个P位点，其激活会抑制许多腺苷酸环化酶激动剂的作用，包括异丙肾上腺素、前列腺素E1、组胺、腺苷、霍乱毒素和福斯高林。
