Katsumata Ryo, Shiotani Akiko, Murao Takahisa, Ishii Manabu, Fujita Minoru, Matsumoto Hiroshi, Haruma Ken
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 710-0192, Japan.
Department of General Internal Medicine 2, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 710-0192, Japan.
J Clin Biochem Nutr. 2018 May;62(3):270-276. doi: 10.3164/jcbn.17-76. Epub 2018 Jan 27.
The gastrointestinal symptoms of irritable bowel syndrome are strongly related to impaired quality of life (QOL), especially in diarrhea-predominant. The gene polymorphisms associated with serotonin, or 5-hydroxytryptamine, alter gastrointestinal symptoms and mental status. We aimed to evaluate the effects of gene polymorphisms on gastrointestinal symptoms, psychological conditions, and QOL, and compare these between patients with diarrhea-predominant irritable bowel syndrome ( = 62) and healthy controls ( = 64). The gene polymorphisms of 5-HTTLPR, 5-HTTVNTR, TPH1 rs453773, and TPH1 rs211105 were evaluated. Gastrointestinal symptoms, depressive state, and QOL were assessed using the Gastrointestinal Symptom Rating Scale, Self-rating Depression Scale, and Short-Form-36. Gene polymorphisms did not significantly differ in frequency between the two groups. The scores for diarrhea, abdominal pain, and indigestion significantly correlated with the physical component summary score. Only the group of patients with diarrhea-predominant irritable bowel syndrome showed a significant correlation between the TPH1 rs211105 T/T genotype and lower scores for role physical and mental health, and higher scores for indigestion and diarrhea. 5-HTTLPR l/s was associated with lower score of role emotional in the diarrhea-predominant irritable bowel syndrome and higher scores in the controls. The gene polymorphisms of 5-hydroxytryptamine signaling effected gastrointestinal symptoms and QOL, especially of the patients with diarrhea-predominant irritable bowel syndrome.
肠易激综合征的胃肠道症状与生活质量受损密切相关，尤其是在腹泻型为主的患者中。与血清素或5-羟色胺相关的基因多态性会改变胃肠道症状和精神状态。我们旨在评估基因多态性对胃肠道症状、心理状况和生活质量的影响，并在腹泻型为主的肠易激综合征患者（n = 62）和健康对照者（n = 64）之间进行比较。评估了5-HTTLPR、5-HTTVNTR、TPH1 rs453773和TPH1 rs211105的基因多态性。使用胃肠道症状评定量表、自评抑郁量表和简明健康调查问卷评估胃肠道症状、抑郁状态和生活质量。两组之间基因多态性的频率没有显著差异。腹泻、腹痛和消化不良的评分与身体成分汇总评分显著相关。仅腹泻型为主的肠易激综合征患者组中，TPH1 rs211105 T/T基因型与角色身体和心理健康评分较低以及消化不良和腹泻评分较高之间存在显著相关性。5-HTTLPR l/s与腹泻型为主的肠易激综合征患者的角色情感评分较低以及对照组评分较高相关。5-羟色胺信号通路的基因多态性影响胃肠道症状和生活质量，尤其是腹泻型为主的肠易激综合征患者。
