Department of General Surgery, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
BMC Gastroenterol. 2021 Nov 12;21(1):426. doi: 10.1186/s12876-021-02012-z.
The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility.
Our data showed an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95 % CI 0.94-6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotypes in the control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs = - 0.415, p = 0.0018; GT: Rs = - 0.457, p = 0.0066), while for the AP group the highest levels of TPH among the TT genotype were associated with lower levels of serotonin (TT: Rs = - 0.749, p < 0.0001, and in the GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs = - 0.738, p = 0.037).
Here, a new insight in the potential role of a selected genetic factor in pancreatitis development was shown. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important points in acute pancreatitis.
血清素及其代谢途径在急性胰腺炎（AP）患者的胰腺正常功能中的作用尚未得到充分研究。色氨酸羟化酶（TPH）作为血清素合成的限速酶，已被认为与各种疾病有关。TPH 基因中的单核苷酸多态性（SNP）已被描述与精神和消化系统疾病有关。本研究旨在探讨 TPH1 基因 rs211105（T/G）多态性与急性胰腺炎患者血清色氨酸羟化酶 1 浓度的关系，并探讨其与急性胰腺炎易感性的关系。
我们的数据显示，在 AP 发生率降低的情况下，位置 rs211105 处存在 T 等位基因与存在相关（OR = 2.47，95%CI 0.94-6.50，p = 0.06）。在对照组中，TT 和 GT 基因型的 TPH 浓度最低与血清素水平升高相关（TT：Rs = -0.415，p = 0.0018；GT：Rs = -0.457，p = 0.0066），而在 AP 组中，TT 基因型的 TPH 水平最高与血清素水平最低相关（TT：Rs = -0.749，p <0.0001，在 GG 基因型中，较高的 TPH 水平与较高的血清素水平相关（GG：Rs = -0.738，p = 0.037）。
本研究显示了一种新的选择遗传因素在胰腺炎发展中的潜在作用的见解。不仅是血清素的代谢途径，而且影响血清素合成的因素也可能是急性胰腺炎的有趣和重要点。
