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内镜超声(EUS)引导下细针穿刺抽吸:一种诊断失代偿期肝硬化患者腹膜结核的新方法——病例系列及文献综述

Endoscopic Ultrasound (EUS) Guided Fine Needle Aspiration: A New Modality to Diagnose Peritoneal Tuberculosis in Presence of Decompensated Cirrhosis-A Case Series and Review of Literature.

作者信息

Daswani Ravi, Kumar Ashish, Singla Vikas, Kaur Gagandeep, Sharma Praveen, Bansal Naresh, Arora Anil

机构信息

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India.

出版信息

J Clin Exp Hepatol. 2018 Jun;8(2):205-209. doi: 10.1016/j.jceh.2017.09.007. Epub 2017 Oct 7.

Abstract

BACKGROUND

The gold-standard for diagnosis is growth of on ascitic fluid or peritoneal culture. Due to the non-specific signs and symptoms of disease, its early diagnosis is difficult, especially in patients with decompensated cirrhosis. The reported sensitivity of ascitic fluid is low and to obtain tissue for peritoneal biopsy in patients with cirrhosis is difficult. Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) is a good alternative to obtain peritoneal tissue for establishing the diagnosis of peritoneal TB.

OBJECTIVE

To assess the role of EUS-FNA in the diagnosis of peritoneal tuberculosis in patients with decompensated cirrhosis.

METHODS

Consecutive patients with peritoneal thickening, ascites and decompensated cirrhosis underwent EUS-FNA from the thickened omentum. Presence of granuloma or demonstration of acid fast bacilli was diagnostic of peritoneal tuberculosis.

RESULTS

A total of 5 patients with CLD underwent EUS-FNA from omentum. FNA cytology revealed granuloma with multinucleated cells in all patients (100%) and AFB stain was positive in 2 of them (40%).

CONCLUSION

We hereby report the use of EUS guided fine needle aspiration (FNA) of peritoneum as a newer, safe and unexplored technique for diagnosis of peritoneal TB.

摘要

背景

诊断的金标准是腹水或腹膜培养发现[具体病菌名称未给出]生长。由于该病的体征和症状不具特异性,其早期诊断困难,尤其是在失代偿期肝硬化患者中。据报道,腹水检查的敏感性较低,且在肝硬化患者中获取组织进行腹膜活检也很困难。内镜超声(EUS)引导下细针穿刺抽吸(FNA)是获取腹膜组织以确立腹膜结核诊断的一种良好替代方法。

目的

评估EUS-FNA在失代偿期肝硬化患者腹膜结核诊断中的作用。

方法

对连续的腹膜增厚、腹水且失代偿期肝硬化患者,从增厚的大网膜进行EUS-FNA。发现肉芽肿或抗酸杆菌可诊断为腹膜结核。

结果

共有5例肝硬化患者接受了大网膜EUS-FNA。FNA细胞学检查显示所有患者(100%)均有含多核细胞的肉芽肿,其中2例(40%)抗酸杆菌染色呈阳性。

结论

我们在此报告将EUS引导下腹膜细针穿刺抽吸(FNA)作为一种更新的、安全且尚未充分探索的腹膜结核诊断技术。

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