Lopatin Yuri
Volgograd State Medical University, Regional Cardiology Centre Volgograd, Russia.
Card Fail Rev. 2018 May;4(1):9-13. doi: 10.15420/cfr.2018:10:1.
The introduction of heart failure (HF) with mid-range ejection fraction (HFmrEF) as a distinct phenotype has achieved its aim of stimulating research into the underlying characteristics, pathophysiology and treatment of HF patients with left ventricular ejection fraction of 40-49 %. Comparison of clinical characteristics, comorbidities, outcomes and prognosis among patients with HF with preserved ejection fraction, HFmrEF and HF with reduced ejection fraction allowed consideration of HFmrEF as an intermediate phenotype, which often resembles HF with reduced ejection fraction more than HF with preserved ejection fraction. The latest findings suggest that patients with HFmrEF seem to benefit from therapies that have been shown to improve outcomes in HF with reduced ejection fraction.
射血分数中度降低的心力衰竭（HFmrEF）作为一种独特的表型被引入，其目的是推动对左心室射血分数为40%-49%的HF患者的潜在特征、病理生理学和治疗方法的研究。对射血分数保留的HF患者、HFmrEF患者和射血分数降低的HF患者的临床特征、合并症、结局和预后进行比较后，HFmrEF被视为一种中间表型，它通常更类似于射血分数降低的HF，而不是射血分数保留的HF。最新研究结果表明，HFmrEF患者似乎能从已被证明可改善射血分数降低的HF患者结局的治疗中获益。
