轻度获得性脑损伤患者的胃肠传输时间和心率变异性
Gastrointestinal transit time and heart rate variability in patients with mild acquired brain injury.
作者信息
Enevoldsen Johannes, Vistisen Simon T, Krogh Klaus, Nielsen Jørgen F, Knudsen Karoline, Borghammer Per, Andersen Henning
机构信息
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Research Centre for Emergency Medicine, Aarhus University, Aarhus, Denmark.
出版信息
PeerJ. 2018 Jun 6;6:e4912. doi: 10.7717/peerj.4912. eCollection 2018.
BACKGROUND
Constipation is suspected to occur frequently after acquired brain injury (ABI). In patients with ABI, heart rate variability (HRV) is reduced suggesting autonomic dysfunction. Autonomic dysfunction may be associated with prolonged gastrointestinal transit time (GITT). The primary aim of this study was to investigate if GITT is prolonged in patients with ABI. Secondarily, HRV and its correlation with GITT was investigated.
METHODS
We included 25 patients with ABI (18 men, median age: 61.3 years, range [30.7-74.5]). GITT was assessed using radio-opaque markers and HRV was calculated from 24-hour electrocardiograms. Medical records were reviewed for important covariates, including primary diagnosis, time since injury, functional independence measure, and use of medication. The GITT assessed in patients was compared to a control group of 25 healthy subjects (18 men, median age: 61.5 years, range [34.0-70.9]).
RESULTS
In ABI patients, the mean GITT was significantly longer than in healthy controls (2.68 days, 95% CI [2.16-3.19] versus (1.92 days, 95% CI [1.62-2.22], = 0.011)). No correlation was found between HRV and GITT.
CONCLUSION
Patients with mild to moderate ABI have prolonged GITT unrelated to the HRV.
背景
推测后天性脑损伤（ABI）后便秘经常发生。在ABI患者中，心率变异性（HRV）降低提示自主神经功能障碍。自主神经功能障碍可能与胃肠道传输时间延长（GITT）有关。本研究的主要目的是调查ABI患者的GITT是否延长。其次，研究HRV及其与GITT的相关性。
方法
我们纳入了25例ABI患者（18例男性，中位年龄：61.3岁，范围[30.7 - 74.5]）。使用不透X线标志物评估GITT，并根据24小时心电图计算HRV。查阅病历以获取重要的协变量，包括初步诊断、受伤后的时间、功能独立性测量和药物使用情况。将患者的GITT与25名健康受试者的对照组（18例男性，中位年龄：61.5岁，范围[34.0 - 70.9]）进行比较。
结果
在ABI患者中，平均GITT显著长于健康对照组（2.68天，95%置信区间[2.16 - 3.19]对比（1.92天，95%置信区间[1.62 - 2.22]，P = 0.011））。未发现HRV与GITT之间存在相关性。
结论
轻度至中度ABI患者的GITT延长，与HRV无关。
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