Teoh Shao Thing, Ogrodzinski Martin P, Ross Christina, Hunter Kent W, Lunt Sophia Y
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States.
Department of Physiology, Michigan State University, East Lansing, MI, United States.
Front Oncol. 2018 May 28;8:174. doi: 10.3389/fonc.2018.00174. eCollection 2018.
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in mouse tumors of differing metastatic propensities using mass spectrometry-based metabolomics. We found that sialic acid metabolism is upregulated in highly metastatic breast tumors. Knocking out a key gene in sialic acid metabolism, , inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases . Thus, the sialic acid pathway may be a new target against metastatic breast cancer.
转移性乳腺癌目前无法治愈。最近有研究表明，不同的代谢途径支持转移性乳腺癌。为了进一步揭示促成乳腺癌转移的代谢途径，我们使用基于质谱的代谢组学方法，研究了具有不同转移倾向的小鼠肿瘤中的代谢差异。我们发现，在高转移性乳腺肿瘤中，唾液酸代谢上调。敲除唾液酸代谢中的一个关键基因，可抑制唾液酸的活化形式——胞苷单磷酸 - 唾液酸的合成，并减少肺转移灶的形成。因此，唾液酸途径可能是对抗转移性乳腺癌的一个新靶点。
