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银屑病关节炎的临床管理。

Clinical management of psoriatic arthritis.

机构信息

Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; VIB Center for Inflammation Research, Unit for Molecular Immunology and Inflammation, Department of Internal Medicine, Ghent University, Ghent, Belgium.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

出版信息

Lancet. 2018 Jun 2;391(10136):2285-2294. doi: 10.1016/S0140-6736(18)30949-8. Epub 2018 Jun 1.

Abstract

Psoriatic arthritis, or the broader term psoriatic disease, refers to an inflammatory disorder that affects multiple organs, including the skin and joints, and that also has related extra-articular manifestations and can have comorbidities. Patients with psoriatic disease have a substantial clinical burden. Early identification leading to timely diagnosis and treatment is crucial to prevent long-term structural damage and disability and the associated socioeconomic consequences. The increase in therapeutic options, such as disease-modifying anti-rheumatic drugs, both biological and targeted synthetic, has revolutionised the treatment of skin and joint disease, and has prompted clinicians to use the full clinical picture of an individual patient to make rational treatment decisions. Current research is also focused on treatment strategies, including treat to target, early remission-induction, and tapering.

摘要

银屑病关节炎,或更广泛的术语银屑病性疾病,是指一种炎症性疾病,影响多个器官,包括皮肤和关节,也有相关的关节外表现,并可能有合并症。患有银屑病性疾病的患者有很大的临床负担。早期识别导致及时诊断和治疗对于预防长期的结构损伤和残疾以及相关的社会经济后果至关重要。治疗选择的增加,如疾病修饰抗风湿药物,包括生物制剂和靶向合成药物,已经彻底改变了皮肤和关节疾病的治疗方法,并促使临床医生根据个体患者的全部临床情况做出合理的治疗决策。目前的研究还集中在治疗策略上,包括靶向治疗、早期缓解诱导和逐渐减少治疗。

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