Urogenital Research Unit, Rio de Janeiro State University, Rio de Janeiro, RJ 20551-030, Brazil.
Asian J Androl. 2018 Sep-Oct;20(5):505-510. doi: 10.4103/aja.aja_28_18.
Erectile dysfunction is a common side effect of finasteride and dutasteride treatments. The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia (BPH) rodent model treated with dutasteride or finasteride. Sixty male rats were divided into the following groups: C, untreated control rats; C + D, control rats receiving dutasteride; C + F, control rats receiving finasteride; H, untreated spontaneously hypertensive rats (SHRs); H + D, SHRs treated with dutasteride; and H + F, SHRs treated with finasteride. Treatments were performed for 40 days, and penises were collected immediately thereafter. The organs were analyzed using histomorphometric methods to determine the cross-sectional penile area, as well as the surface density (Sv) of smooth muscle fibers, connective tissue, elastic system fibers, and sinusoidal spaces of the corpus cavernosum. The results were compared using a one-way ANOVA with Bonferroni's posttest. Groups C + D and C + F had a significantly smaller penile cross-sectional area, but more elastic system fiber Sv compared to Group C. Group C + D showed less smooth muscle Sv, and Group H showed more connective tissue but a smaller sinusoidal space Sv in the corpus cavernosum compared to Group C. Groups H + D and H + F had less smooth muscle Sv than Group H. Group H + D also had more connective tissue and elastic system fiber Sv than Group H. Both dutasteride and finasteride promoted penile modifications in the control rat penis, although this affect was greater in Group H animals. In this rodent model, dutasteride was the drug that most affected the corpus cavernosum.
勃起功能障碍是非那雄胺和度他雄胺治疗的常见副作用。本研究的目的是使用良性前列腺增生（BPH）啮齿动物模型研究度他雄胺或非那雄胺治疗后阴茎的结构变化。将 60 只雄性大鼠分为以下几组：C 组，未处理的对照组大鼠；C+D 组，接受度他雄胺的对照组大鼠；C+F 组，接受非那雄胺的对照组大鼠；H 组，未处理的自发性高血压大鼠（SHR）；H+D 组，接受度他雄胺的 SHR 组；H+F 组，接受非那雄胺的 SHR 组。治疗进行了 40 天，之后立即收集阴茎。使用组织形态计量学方法分析器官，以确定阴茎的横截面积，以及海绵体平滑肌纤维、结缔组织、弹性系统纤维和窦状隙的表面密度（Sv）。使用单因素方差分析和 Bonferroni 事后检验比较结果。与 C 组相比，C+D 组和 C+F 组的阴茎横截面积明显较小，但弹性系统纤维 Sv 较多。与 C 组相比，C+D 组的平滑肌 Sv 较少，H 组的海绵体中结缔组织较多，但窦状隙 Sv 较小。与 H 组相比，H+D 组和 H+F 组的平滑肌 Sv 较少。与 H 组相比，H+D 组的结缔组织和弹性系统纤维 Sv 也较多。度他雄胺和非那雄胺都促进了对照组大鼠阴茎的改变，尽管 H 组动物的影响更大。在这种啮齿动物模型中，度他雄胺是对海绵体影响最大的药物。
