Da Silva Marcello H A, Medeiros Jorge L, Costa Waldemar S, Sampaio Francisco J B, De Souza Diogo B
Urogenital Research Unit, Rio De Janeiro State University, Rio De Janeiro, Brazil.
Fundação Educacional Dom André Arcoverde, Valença, Brazil.
Aging Male. 2020 Dec;23(5):1009-1015. doi: 10.1080/13685538.2019.1653839. Epub 2019 Aug 20.
The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model.
Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering values <.05 as significant.
The smooth muscle density decreased by 28.6% and 21.4% in BPH + D and BPH + DS, respectively, when compared to the BPH group. The sinusoid space density reduced by 32.2% in BPH, when compared to the Ctrl group; this density was also reduced by 22.6% in BPH + D, when compared to the BPH group. The density of the elastic fibers increased 51.6% and 65.6% in BPH + D and BPH + DS, when compared to the BPH group.
Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil did not prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.
本研究旨在调查度他雄胺与西地那非联合治疗是否能预防良性前列腺增生（BPH）啮齿动物模型阴茎的结构变化。
将32只成年雄性大鼠分为以下几组：Ctrl组，未治疗的对照大鼠；BPH组，未治疗的自发性高血压大鼠（SHR）；BPH + D组，接受度他雄胺治疗的SHR；BPH + DS组，接受度他雄胺和西地那非治疗的SHR。所有治疗均持续40天，之后收集阴茎进行组织形态计量分析。通过单因素方差分析和Bonferroni事后检验比较结果，将P值<0.05视为有统计学意义。
与BPH组相比，BPH + D组和BPH + DS组的平滑肌密度分别降低了28.6%和21.4%。与Ctrl组相比，BPH组的窦状隙空间密度降低了32.2%；与BPH组相比，BPH + D组的该密度也降低了22.6%。与BPH组相比，BPH + D组和BPH + DS组的弹性纤维密度分别增加了51.6%和65.6%。
度他雄胺治疗促进了该BPH模型海绵体的形态学变化。西地那非联合治疗未能预防度他雄胺引起的形态学变化；相反，它还促进了弹性纤维的进一步增加。
