Rafiemanesh Hosein, Lotfi Zahra, Bakhtazad Sima, Ghoncheh Mahshid, Salehiniya Hamid
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Biotechnology, Guilan University of Medical Sciences, Rasht, Iran.
J Cancer Res Ther. 2018 Apr-Jun;14(3):532-536. doi: 10.4103/0973-1482.172134.
Bladder cancer is the ninth common cancer in the world, the third common cancer among men in the Arabic and Western Asian countries, and the second in some regions of Iran (a country in the Middle East). There was no study on the epidemiological and histological trend of bladder cancer in Iran. This study aimed to the epidemiological and histological trend of bladder cancer in Iran.
In this study, data were extracted from annual cancer registry reports of Iranian Ministry of Health between 2003 and 2008. Standardized incidence rates were calculated using the world standard population and incidence rate was calculated by age groups, sex, and histological type. Data on epidemiologic trend and histology were analyzed using Joinpoint software package.
A total of 23,291 cases were reported. Almost 17.70% (4127 cases) were women and 82.30% (19,170 cases) men. The sex ratio (male to female) was 4.65. Joinpoint analysis showed the significant increased trend of age-standardized incidence rate (ASIR) for both sexes. The annual percentage change of standardized incidence rate was 11.5 (confidence interval [CI]: 9.0-14.0) in women and 10.8 (CI: 8.0-13.6) in men. Two histological types of transitional cell carcinoma (TCC), not otherwise specified and papillary TCC included 43.89% and 49.86% of all cancer cases, respectively.
According to this study the trend of ASIR of bladder cancer in Iran is rising, so it is necessary to conduct further researches in future to provide accurate information on the cancer and investigate related risk factors and implement prevention programs in Iran.
膀胱癌是全球第九大常见癌症，在阿拉伯和西亚国家中是男性第三大常见癌症，在伊朗（中东国家）的一些地区则是第二大常见癌症。此前尚无关于伊朗膀胱癌流行病学和组织学趋势的研究。本研究旨在探讨伊朗膀胱癌的流行病学和组织学趋势。
在本研究中，数据取自伊朗卫生部2003年至2008年的年度癌症登记报告。使用世界标准人口计算标准化发病率，并按年龄组、性别和组织学类型计算发病率。使用Joinpoint软件包分析流行病学趋势和组织学数据。
共报告了23291例病例。其中女性占近17.70%（4127例），男性占82.30%（19170例）。男女比例为4.65。Joinpoint分析显示，两性的年龄标准化发病率（ASIR）均呈显著上升趋势。女性标准化发病率的年百分比变化为11.5（置信区间[CI]：9.0 - 14.0），男性为10.8（CI：8.0 - 13.6）。两种未另行指定的移行细胞癌（TCC）组织学类型和乳头状TCC分别占所有癌症病例的43.89%和49.86%。
根据本研究，伊朗膀胱癌的ASIR呈上升趋势，因此未来有必要进一步开展研究，以提供有关该癌症的准确信息，调查相关危险因素，并在伊朗实施预防计划。
