Salehi Alireza, Khezri Abdul-aziz, Malekmakan Leila, Aminsharifi Alireza
Epidemiology Department, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Asian Pac J Cancer Prev. 2011;12(5):1323-7.
Bladder cancer is the second most common malignancy of the genitourinary tract worldwide after prostate cancer. However, in Iran it is the most common cancer of the genitourinary system and the third most common cancer in males. The increasing trend in bladder cancer incidence in recent decades, along with the lack of research on this malignancy in Iran, make epidemiologic research important in light of its preventability through early recognition and limiting exposure to risk factors. The present study aimed to assess the epidemiology of bladder cancer in Shiraz, a large city in southern Iran, during a 2-year period.
The data for this study were obtained from the population-based cancer registry of the Vice-Chancellery for Health Affairs of Shiraz University of Medical Sciences and Shiraz hospitals between March 1, 2007 and March 1, 2009. Demographic, clinical and pathological aspects of 216 patients with bladder cancer were investigated through careful review of their medical records. Statistical analyses were performed with SPSS software. P values less than 0.05 were considered statistically significant.
We analyzed data for 179 (82.9%) men and 37 (17.1%) women (mean age of 65.1∓12.7 years). Tobacco and opium use were found in 109 (65.3%) and 44 (34.1%) patients, respectively. Cigarette smokers and water pipe smokers were mostly men (P=0.001 and P=0.04, respectively). The most common type of tumor was transitional cell carcinoma (95.7%) and most tumors were of low malignant potential grade (39.7%). Nearly half of the patients suffered recurrence.
Comparisons with previous studies showed that bladder cancer tends to appear slightly more often in the elderly and that the tumors tend to have a higher grade of malignancy in our region. There is a need for more epidemiologic studies on the trends in the incidence and other epidemiologic indices.
膀胱癌是全球仅次于前列腺癌的第二大常见泌尿生殖系统恶性肿瘤。然而，在伊朗，它是泌尿生殖系统最常见的癌症，也是男性中第三大常见癌症。近几十年来膀胱癌发病率呈上升趋势，且伊朗缺乏对这种恶性肿瘤的研究，鉴于其可通过早期识别和限制危险因素暴露来预防，因此流行病学研究具有重要意义。本研究旨在评估伊朗南部大城市设拉子在两年期间膀胱癌的流行病学情况。
本研究的数据来自设拉子医科大学卫生事务副校长办公室和设拉子医院基于人群的癌症登记处，时间跨度为2007年3月1日至2009年3月1日。通过仔细查阅216例膀胱癌患者的病历，对其人口统计学、临床和病理方面进行了调查。使用SPSS软件进行统计分析。P值小于0.05被认为具有统计学意义。
我们分析了179名（82.9%）男性和37名（17.1%）女性的数据（平均年龄65.1±12.7岁）。分别有109例（65.3%）和44例（34.1%）患者有吸烟和吸食鸦片史。吸烟者和水烟吸食者大多为男性（P值分别为0.001和0.04）。最常见的肿瘤类型是移行细胞癌（95.7%），且大多数肿瘤为低恶性潜能分级（39.7%）。近一半的患者出现复发。
与先前研究相比，表明膀胱癌在老年人中出现的频率略高，且我们地区的肿瘤恶性程度往往更高。需要对发病率趋势和其他流行病学指标进行更多的流行病学研究。
