Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Org Biomol Chem. 2018 Jul 4;16(26):4753-4777. doi: 10.1039/c8ob00900g.
The development of suitable chiral catalysts, which represent powerful, economically feasible tools for the preparation of optically active organic molecules, is a fundamental endeavour in synthetic chemistry. Chiral phosphoric acids derived from axially chiral 1,1'-bi-2-naphthol (BINOL) are a widely used class of strong Brønsted acid catalysts and have been applied successfully in many asymmetric catalyzed reactions. Accordingly, the development and application of chiral spirocyclic phosphoric acids derived from axially chiral 1,1'-spirobiindane-7,7'-diol (SPINOL) have received increasing attention in the last eight years. This review covers the synthetic methods and the application of chiral spirocyclic phosphoric acids in asymmetric catalysis.
发展合适的手性催化剂是合成化学中的一项基础工作，手性磷酸是一类广泛应用的强布朗斯特酸催化剂，由轴手性 1,1'-联萘酚（BINOL）衍生而来，在手性催化反应中取得了成功。因此，在过去的八年中，人们越来越关注由轴手性螺环双茚满-7,7'-二醇（SPINOL）衍生而来的手性螺环磷酸的开发和应用。这篇综述涵盖了手性螺环磷酸的合成方法及其在不对称催化中的应用。
