Winters Karen R, Montchamp Jean-Luc
Department of Chemistry and Biochemistry, Texas Christian University, Fort Worth, Texas 76129, United States.
Beilstein J Org Chem. 2022 Oct 17;18:1471-1478. doi: 10.3762/bjoc.18.154. eCollection 2022.
A series of -stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. In order to eliminate the need for -symmetry in common CPAs, various scaffolds containing -symmetrical thiophosphorus acids were chosen. These new compounds were synthesized and evaluated in the asymmetric transfer hydrogenation of 2-phenylquinoline. Although the efficacy of the thiophosphorus acids was disappointing for this reaction, the work should be useful for developing structural design elements.
合成了一系列具有立体中心的手性磷酸（CPAs），以确定高效不对称有机催化的要求。为了消除常见CPAs中对对称的需求，选择了各种含有对称硫代磷酸的骨架。合成了这些新化合物，并在2-苯基喹啉的不对称转移氢化反应中进行了评估。尽管硫代磷酸对该反应的效果令人失望，但这项工作对于开发结构设计元素应该是有用的。
