Cavalcanti-de-Albuquerque João Paulo, Kincheski Grasielle Clotildes, Louzada Ruy Andrade, Galina Antônio, Pierucci Anna Paola Trindade Rocha, Carvalho Denise P
Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Institute of Nutrition Josue de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Exp Physiol. 2018 Aug;103(8):1076-1086. doi: 10.1113/EP086916. Epub 2018 Jul 12.
What is the central question of this study? How does an acute session of exercise affect food intake of male Wistar rats? What is the main finding and its importance? Food intake in male Wistar rats is decreased in the first hour after physical exercise independent of the intensity. Moreover, high-intensity exercise potentiates the anorexic effect of peripheral glucose administration. This work raises new feeding-related targets that would explain how exercise drives body weight loss.
Obesity has emerged as a critical metabolic disorder in modern society. An adequate lifestyle with a well-oriented programme of diet and physical exercise (PE) can prevent or potentially even cure obesity. Additionally, PE might lead to weight loss by increasing energy expenditure and decreasing hunger perception. In this article, we hypothesize that an acute exercise session would potentiate the glucose inhibitory effects on food intake in male Wistar rats. Our data show that moderate- or high-intensity PE significantly decreased food intake, although no changes in the expression of feeding-related neuropeptide in the arcuate nucleus of the hypothalamus were found. Exercised animals demonstrated a reduced glucose tolerance and increased blood insulin concentration. Intraperitoneal administration of glucose decreased food intake in control animals. In the animals submitted to moderate-intensity PE, the decrease in food intake promoted by glucose was similar to controls; however, an interaction was observed when glucose was injected in the high-intensity PE group, in which food intake was significantly lower than the effect produced by glucose alone. A different pattern of expression was observed for the monocarboxylate transporter isoforms (MCT1, 2 and 4) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFBP3) in the hypothalamus, which was dependent on the exercise intensity. In conclusion, PE decreases food intake independently of the intensity. However, an interaction between PE and the anorexic effect of glucose is only observed when a high-intensity exercise is performed. These data show an essential role of exercise intensity in the modulation of the glucose inhibitory effect on food intake.
本研究的核心问题是什么？一次急性运动对雄性Wistar大鼠的食物摄入量有何影响？主要发现及其重要性是什么？雄性Wistar大鼠在体育锻炼后的第一小时内食物摄入量减少，且与运动强度无关。此外，高强度运动增强了外周葡萄糖给药的厌食作用。这项研究提出了新的与进食相关的靶点，这将解释运动如何促使体重减轻。
肥胖已成为现代社会中一种关键的代谢紊乱疾病。拥有合理饮食和体育锻炼（PE）计划的适当生活方式可以预防甚至可能治愈肥胖。此外，体育锻炼可能通过增加能量消耗和降低饥饿感来导致体重减轻。在本文中，我们假设一次急性运动会增强葡萄糖对雄性Wistar大鼠食物摄入的抑制作用。我们的数据表明，中等强度或高强度的体育锻炼显著降低了食物摄入量，尽管在下丘脑弓状核中未发现与进食相关的神经肽表达有变化。运动后的动物表现出葡萄糖耐量降低和血液胰岛素浓度升高。腹腔注射葡萄糖可降低对照动物的食物摄入量。在进行中等强度体育锻炼的动物中，葡萄糖促进的食物摄入量减少与对照组相似；然而，当在高强度体育锻炼组中注射葡萄糖时，观察到一种相互作用，即食物摄入量显著低于单独使用葡萄糖所产生的效果。在下丘脑中观察到单羧酸转运体亚型（MCT1、2和4）和6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3（PFKFBP3）的不同表达模式，这取决于运动强度。总之，体育锻炼无论强度如何都会降低食物摄入量。然而，只有在进行高强度运动时才会观察到体育锻炼与葡萄糖厌食作用之间的相互作用。这些数据表明运动强度在调节葡萄糖对食物摄入的抑制作用中起着重要作用。
