Roger Manuela, Martínez Juan, Peiró Gloria, Aparicio Jose Ramón, Ruiz Francisco, Compañy Luís, Casellas Juan Antonio
Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante, España.
Unidad de Endoscopia Digestiva, Hospital General Universitario de Alicante.
Rev Esp Enferm Dig. 2018 Jul;110(7):446-450. doi: 10.17235/reed.2018.4200/2016.
To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC).
We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples.
Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm.
Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDAC.
评估通过内镜超声引导下细针穿刺活检（EUS-FNA）获取的胰腺样本中组织蛋白酶的表达情况，并研究其与胰腺导管腺癌（PDAC）分期的关系。
我们前瞻性纳入了接受EUS-FNA检查的实性胰腺肿块患者。在FNA样本中测定组织蛋白酶B、L、S和H的表达。
共进行了17次FNA。所有细胞学材料均来自PDAC。组织蛋白酶的表达大多较低（B为65%，L为23%，S为76%，H为41%）。我们发现表达水平与肿瘤的扩展之间没有相关性。
PDAC细胞学材料中组织蛋白酶的表达各不相同，但在术前诊断中仍难以发挥作用。组织蛋白酶的表达水平与PDAC的扩展之间没有相关性。
