白细胞介素-6和肿瘤生长因子-β是特发性鼻出血的危险因素。

Interleukin-6 and Tumor Growth Factor-β are Risk Factors for Idiopathic Epistaxis.

作者信息

Rahmanzadeh-Shahi Soheila, Golshiri-Isfahani Ali, Fathollahi Mahmood Sheikh, Rezayati Mohammadtaghi, Bahramabadi Reza, Afrooz Mohammadreza, Asadikaram Gholamreza, Kennedy Derek, Arababadi Mohammad Kazemi

机构信息

Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Department of Otolaryngology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

出版信息

Lab Med. 2018 Oct 11;49(4):329-341. doi: 10.1093/labmed/lmy017.

DOI:10.1093/labmed/lmy017

PMID:29893909

Abstract

OBJECTIVE

To evaluate the serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, tumor growth factor (TGF)-β, endothelin, and immunoglobulin (Ig)E in patients with idiopathic epistaxis, compared with healthy control individuals.

METHODS

Serum levels of IL-6, IL-8, TNF-α, TGF-β, endothelin, and IgE were evaluated in 110 patients with idiopathic epistaxis and 100 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique.

RESULTS

Serum levels of IL-6 (P <.001) and TGF-β (P = .001) were significantly increased in patients with idiopathic epistaxis, compared with controls. TNF-α serum levels were significantly increased in male patients, compared with female patients (P = .053). We observed decreased antihistamine levels and increased expression of TGF-β (P = .02) and TNF-α (P = .02), respectively.

CONCLUSIONS

IL-6 and TGF-β appear to participate in the pathogenesis of idiopathic epistaxis. TNF-α may be considered a risk factor for male patients in developing epistaxis. Antihistamines may inhibit angiogenesis by decreasing expression of TGF-β and increasing expression of TNF-α.

摘要