Lenhard M. James, Rockwell Karen, Tran Kim
Del Med J. 2017 May;89(5):142-146.
As patients with diabetes continue to have greater problems with obesity, the need for more medications and higher doses of insulin has increased. Some patients are so insulin resistant that they require U-500 insulin.
QUESTIONS/PURPOSES: All insulins carry the risk of hypoglycemia. Despite being the most potent insulin available, the methodology for describing U-500 insulin administration varies. This paper examines the properties of U-500 insulin and suggests a unified method of defining how it is administered.
A literature search for English language articles that reference U-500 insulin was performed. The 51 articles, and additional websites as applicable, were independently reviewed.
Now that U-500 insulin has a specific syringe and a pen, all patients who use this should be converted to one of these two devices. The insulin dose should be described as the number of units administered.
U-500 insulin is a potent formulation and carries the risk of hypoglycemia. A unified method of administration is now available, and the description of its use should reflect the number of units administered.
随着糖尿病患者肥胖问题日益严重，对更多药物和更高剂量胰岛素的需求也在增加。一些患者胰岛素抵抗严重，需要使用U - 500胰岛素。
问题/目的：所有胰岛素都有低血糖风险。尽管U - 500胰岛素是现有最强效的胰岛素，但其给药方法的描述却各不相同。本文研究了U - 500胰岛素的特性，并提出一种统一的方法来定义其给药方式。
检索了引用U - 500胰岛素的英文文献。对51篇文章以及适用的其他网站进行了独立评审。
既然U - 500胰岛素有专用注射器和笔，所有使用该药的患者都应改用这两种器械之一。胰岛素剂量应以给药的单位数来描述。
U - 500胰岛素是一种强效制剂，有低血糖风险。现在有了统一的给药方法，其使用说明应反映给药的单位数。
