Yang S, Duan W, Kong W, Zhu L, Wu Y
Eur J Gynaecol Oncol. 2016 Aug;37(4):539-542.
To preliminarily evaluate the clinical significance of different methods in diagnosis of cervical glandular intraepithelial neo- plasia (CGIN).
Clinical manifestations, ThinPrep cytologic test (TCT), cervical biopsy, and pathological features of 106 patients with CGIN admitted to Beijing Obstetrics and Gynecology Hospital between 2008 and 2011 were retrospectively analyzed.
Among 146 cases diagnosed with CGIN, 87 (59.6%) had L-CGIN and 59 (40.4%) H-CGIN. Thirty-seven patients (25.6%) were found to have simple CGIN and 109 (74.6%) had CGIN complicated with cervical intraepithelial neoplasia (CIN). TCT revealed atypical glandular cells (AGC) in 20 patients (13.7%), six of whom had L-CGIN (6.9%) and 14 (23.7%) had H-CGIN with statistical significance between two groups (p < 0.05). TCT detected AGC in 13 cases (35.1%) with simple CGIN and seven with mixed CGIN (6.4%) (P<0.05). Endocervical curettage (ECC) revealed AGC abnormality in ten cases (25.6%). Cervical biopsy under colposcope revealed 32 patients (22.9%) had CGIN, including 15 L-CGIN (18.3%), and 17 H-CGIN (29.3%) with no statistical significance (p > 0.05). Among those diagnosed with CGIN by colposcope-assisted cervical biopsy, 19 (51.4%) had simple CGIN and 13 (11.9%) mixed CGIN (p < 0.05).
Preoperative diagnostic rate of simple CGIN was higher than CGIN complicated with CIN.
初步评估不同方法在宫颈腺上皮内瘤变（CGIN）诊断中的临床意义。
回顾性分析2008年至2011年在北京妇产医院收治的106例CGIN患者的临床表现、薄层液基细胞学检测（TCT）、宫颈活检及病理特征。
在146例诊断为CGIN的病例中，87例（59.6%）为低级别CGIN（L-CGIN），59例（40.4%）为高级别CGIN（H-CGIN）。37例患者（25.6%）为单纯性CGIN，109例（74.6%）为合并宫颈上皮内瘤变（CIN）的CGIN。TCT检查发现20例患者（13.7%）有非典型腺细胞（AGC），其中6例为L-CGIN（6.9%），14例为H-CGIN（23.7%），两组间差异有统计学意义（p<0.05）。TCT在13例单纯性CGIN患者（35.1%）及7例合并性CGIN患者（6.4%）中检测到AGC（P<0.05）。宫颈管搔刮术（ECC）发现10例患者（25.6%）AGC异常。阴道镜下宫颈活检发现32例患者（22.9%）有CGIN，其中15例为L-CGIN（18.3%），17例为H-CGIN（29.3%），差异无统计学意义（p>0.05）。在经阴道镜辅助宫颈活检诊断为CGIN的患者中，19例（51.4%）为单纯性CGIN，13例（11.9%）为合并性CGIN（p<0.05）。
单纯性CGIN的术前诊断率高于合并CIN的CGIN。
