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质谱法在合成与分析中的应用。

Mass Spectrometry for Synthesis and Analysis.

机构信息

Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, USA; email:

Current affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA.

出版信息

Annu Rev Anal Chem (Palo Alto Calif). 2018 Jun 12;11(1):1-28. doi: 10.1146/annurev-anchem-061417-125820.

Abstract

Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Work from the Aston Laboratories at Purdue University's Department of Chemistry is described here, with an emphasis on accelerated reactions of ions in solution and small-scale synthesis; ion/surface collision processes, including surface-induced dissociation (SID) and ion soft landing; and applications to tissue imaging. Our special interest in chirality and the chemistry behind the origins of life is also featured together with the exciting area of tissue diagnostics.

摘要

质谱是离子的科学和技术。因此,它涉及产生离子、测量其性质、跟踪其反应、分离它们以及利用它们来构建和转化材料。仪器是这些活动的重要组成部分,而分析应用是其中的一个驱动力。本文描述了普渡大学化学系阿斯顿实验室的工作,重点是溶液中离子的加速反应和小规模合成;离子/表面碰撞过程,包括表面诱导解离(SID)和离子软着陆;以及在组织成像中的应用。我们对手性和生命起源背后的化学特别感兴趣,同时也关注组织诊断学这个令人兴奋的领域。

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