Hata Toshiyuki, Kanenishi Kenji, AboEllail Mohamed Ahmed Mostafa, Mori Nobuhiro, Koyano Kosuke, Kato Ikuko, Kusaka Takashi
Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.
Department of Pediatrics, Kagawa University Graduate School of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.
J Perinat Med. 2019 Feb 25;47(2):207-211. doi: 10.1515/jpm-2018-0114.
To assess the effect of psychotropic drugs on fetal behavior using four-dimensional (4D) ultrasound in the third trimester of pregnancy.
Fetal behavior was assessed using Kurjak's antenatal neurodevelopmental test (KANET) using 4D ultrasound between 28 and 36 weeks of gestation. Thirty healthy (control group) and 10 psychotropic-drug-administered pregnant (case group) women were studied. The total value of the KANET score and values of each parameter (eight parameters) were compared between the two groups.
The total KANET score was normal (except for one fetus in the case group: total score of 9) in both groups, and there was no significant difference in the total KANET score. When individual KANET parameters were compared, no significant differences were noted in any of the eight parameters.
Our results showed that there is no difference in fetal behavior between fetuses of normal pregnant women and those of psychotropic-drug-administered pregnant women in the third trimester of pregnancy. These results suggest that psychotropic drugs may not affect fetal behavioral development in utero. However, the data and their interpretation in the present study should be taken with some degree of caution because of the small number of subjects studied. Further studies involving a larger sample size are needed to assess the effect of psychotropic drugs on fetal neurobehavior during pregnancy.
利用四维（4D）超声评估孕期晚期精神药物对胎儿行为的影响。
在妊娠28至36周期间，使用库尔亚克产前神经发育测试（KANET）和4D超声评估胎儿行为。研究了30名健康孕妇（对照组）和10名服用精神药物的孕妇（病例组）。比较两组之间KANET评分的总分以及每个参数（八个参数）的值。
两组的KANET总分均正常（病例组中有一个胎儿除外：总分9分），且KANET总分无显著差异。比较KANET各个参数时，八个参数中的任何一个均未发现显著差异。
我们的结果表明，孕期晚期正常孕妇的胎儿与服用精神药物的孕妇的胎儿在行为上没有差异。这些结果表明，精神药物可能不会影响子宫内胎儿的行为发育。然而，由于本研究的受试者数量较少，对本研究中的数据及其解释应持一定程度的谨慎态度。需要进行涉及更大样本量的进一步研究，以评估精神药物对孕期胎儿神经行为的影响。
