兰伯特-伊顿肌无力综合征中的循环T细胞亚群
Circulating T cell subsets in the Lambert-Eaton myasthenic syndrome.
作者信息
Robb S A, Bowley T J, Willcox H N, Newsom-Davis J
出版信息
J Neurol Neurosurg Psychiatry. 1985 Jun;48(6):501-5. doi: 10.1136/jnnp.48.6.501.
Peripheral blood T cell subsets were measured using monoclonal antibodies and a fluorescence activated cell sorter in 15 untreated patients with Lambert-Eaton myasthenic syndrome (nine with small cell carcinoma, one undifferentiated epithelial tumour (ca-LEMS], five with no demonstrable tumour (non-ca-LEMS), 10 age-matched healthy controls and 10 patients with small cell carcinoma without neurological disease. OKT8+ (suppressor/cytotoxic) T cells were significantly decreased in ca-LEMS compared with non-ca LEMS (p less than 0.001) ca-controls (p less than 0.01) and healthy controls (p less than 0.001). In one patient depressed OKT8+ T cells antedated clinically evident tumour by five months. OKT3+ (total) and OKT4+ (helper) T cells were similar in ca-LEMS, non-ca LEMS and controls. The mechanism underlying the loss of circulating OKT8+ T cells in ca-LEMS is unknown, but these changes may help to predict the presence of carcinoma in this disease.
使用单克隆抗体和荧光激活细胞分选仪对15例未经治疗的兰伯特-伊顿肌无力综合征患者的外周血T细胞亚群进行检测，其中9例合并小细胞癌，1例为未分化上皮肿瘤（癌性兰伯特-伊顿肌无力综合征），5例未发现肿瘤（非癌性兰伯特-伊顿肌无力综合征），10例年龄匹配的健康对照者以及10例无神经系统疾病的小细胞癌患者。与非癌性兰伯特-伊顿肌无力综合征（p<0.001）、癌性对照者（p<0.01）和健康对照者（p<0.001）相比，癌性兰伯特-伊顿肌无力综合征患者的OKT8+（抑制/细胞毒性）T细胞显著减少。在1例患者中，OKT8+ T细胞减少在临床上明显出现肿瘤前5个月就已出现。癌性兰伯特-伊顿肌无力综合征、非癌性兰伯特-伊顿肌无力综合征和对照者的OKT3+（总）和OKT4+（辅助）T细胞相似。癌性兰伯特-伊顿肌无力综合征患者循环OKT8+ T细胞减少的潜在机制尚不清楚，但这些变化可能有助于预测该疾病中癌的存在。
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