Compston D A, Hughes P J
J Neuroimmunol. 1984 Apr;6(2):105-14. doi: 10.1016/0165-5728(84)90031-6.
Serial studies of lymphocyte sub-populations in patients with multiple sclerosis (MS) show periodic reductions in OKT8 cells (%). This alteration is neither immunologically nor disease-specific and also occurs in some apparently healthy normal individuals. In twice-monthly serial studies of lymphocyte sub-populations carried out over a 6-month period, we have found significant reductions in OKT8 cells on at least 2 occasions in 9/9 patients, 7/7 spouses and 3/11 siblings, but rarely in unrelated controls living in the same city. Abnormalities in these unaffected people occurred at the same time as those seen in their affected relative. Cyclical reduction in OKT8 cells is probably one factor associated with susceptibility to MS, perhaps only abnormal in terms of the frequency and duration with which it occurs, and may be related to environmental conditions affecting patients with MS and their close contacts but not most other unaffected individuals.
对多发性硬化症（MS）患者淋巴细胞亚群的系列研究显示，OKT8细胞（%）出现周期性减少。这种改变既不是免疫特异性的，也不是疾病特异性的，在一些看似健康的正常个体中也会出现。在为期6个月、每月进行两次的淋巴细胞亚群系列研究中，我们发现9/9例患者、7/7例配偶和3/11例兄弟姐妹中，至少有2次出现OKT8细胞显著减少，但在居住在同一城市的无关对照中很少出现。这些未患病个体的异常情况与他们患病亲属的异常情况同时出现。OKT8细胞的周期性减少可能是与MS易感性相关的一个因素，也许只是在其发生的频率和持续时间方面异常，并且可能与影响MS患者及其密切接触者但不影响大多数其他未患病个体的环境条件有关。
