Jacob Jason, Kugelman Lisa
Department of Medicine, Hartford Hospital, Connecticut, USA.
Hartford Dermatology Associates, West Hartford, Connecticut, USA.
Cutis. 2018 May;101(5):378;380;385.
Squamoid eccrine ductal carcinoma (SEDC) is an extremely rare cutaneous tumor of unknown etiology. We report the case of a 77-year-old man with a history of treated chronic lymphocytic leukemia along with numerous basal cell and squamous cell carcinomas who presented for evaluation of a 5-cm, stellate, sclerotic plaque on the left chest of approximately 2 years' duration and a suspicious 3-mm pink papule on the right nasal sidewall of 2 months' duration. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from the undersurface of the epidermis, favoring a diagnosis of SEDC. It was later determined that the patient had distant metastasis of SEDC. This report of an immunocompromised patient with SEDC is a rare case of distant metastasis of SEDC. A review of the literature on the diagnosis, treatment, and surveillance of SEDC also is provided.
鳞状样小汗腺导管癌（SEDC）是一种病因不明的极其罕见的皮肤肿瘤。我们报告了一例77岁男性病例，该患者有慢性淋巴细胞白血病治疗史，同时患有多处基底细胞癌和鳞状细胞癌，此次因左胸部出现一个持续约2年的5厘米星芒状硬化斑块以及右鼻侧壁出现一个持续2个月的可疑3毫米粉红色丘疹前来评估。这两个病变的初始组织学检查均显示为具有鳞状和导管分化的癌，起源于表皮下表面，倾向于诊断为SEDC。后来确定该患者存在SEDC远处转移。这例免疫功能低下患者发生SEDC的报告是SEDC远处转移的罕见病例。本文还提供了关于SEDC诊断、治疗及监测的文献综述。
