Kobas Manuela, Bickle Graz Myriam, Truttmann Anita Carmen, Giannoni Eric, Meylan Pascal, Asner Sandra Andrea
Faculty of Biology and Medicine, University of Lausanne, Switzerland.
Follow-up Unit, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Switzerland / Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Switzerland.
Swiss Med Wkly. 2018 Jun 12;148:w14627. doi: 10.4414/smw.2018.14627. eCollection 2018.
Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown.
(1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection.
This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014.
Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection.
All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection.
先天性巨细胞病毒（cCMV）感染是先天性感音神经性听力损失（SNHL）的主要非遗传病因；然而，cCMV感染的真正影响仍不明确。
（1）确定1999年至2014年在洛桑大学医院诊断出的无症状和有症状的cCMV感染病例数；（２）描述cCMV感染婴儿的听力学和神经发育结局；（3）比较母亲为原发性感染与非原发性感染的婴儿的临床结局。
这是一项对1999年至2014年在洛桑大学医院诊断为cCMV感染的新生儿进行的单中心、观察性、探索性回顾性研究。
共识别出50例cCMV感染新生儿；39例（78%）出生时出现症状，其中29例（74%）有神经系统症状。12名儿童（24%）随后出现了异常的听力学和/或神经发育结局。母亲为非原发性感染的新生儿出生时出现症状的情况比母亲为原发性感染的新生儿更常见。
所有随后出现SNHL或神经发育异常的婴儿出生时均有症状。母亲为原发性感染和非原发性感染的婴儿观察到相似的长期神经发育和听力学结局。
