Electrochemistry Research Group, Department of Chemistry, St. Joseph's College, Lalbagh Road, Bangalore, 560027, Karnataka, India.
Electrochemistry Research Group, Department of Chemistry, St. Joseph's College, Lalbagh Road, Bangalore, 560027, Karnataka, India.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:144-151. doi: 10.1016/j.colsurfb.2018.06.002. Epub 2018 Jun 4.
Due to the enforcement of regulatory restrictions to prevent risk to human health from Bisphenol A (BPA), its structural analogue Bisphenol F (BPF) has been introduced into the market as an alternative. But however recent studies describe BPF as an effectual endocrine disruptor. Hence, there is an indispensible need for research concerning BPF human and environmental exposure level. In this work, we have elicited the development of an economical electrochemical sensor, to quantify and investigate in detail the electrochemical behavior of BPF using carbon paste electrode (CPE) modified with zinc oxide reduced graphene nanocomposite (ZnO/G) and cetyltrimethylammonium bromide (CTAB). The ZnO/G was synthesized using Hummers method and characterized by spectroscopic techniques. Under optimal conditions, conductive and biocompatible ZnO/G/CTAB/MCPE offered ultra sensitivity for BPF recognition by Differential Pulse Voltammetry (DPV), with a detection limit of 0.06 μM. Lowering of activation energy for electro-oxidation of BPF and absence of peak for interfering molecule Ascorbic acid (AA) makes it an unique sensor for the detection of BPF with significant analytical advantage over other electrodes reported in literature. Versatility of the electrode was demonstrated by applying it to real time analysis of human body fluids, canned beverage and different water samples fortified with BPF. The satisfactory recoveries obtained, consequently authenticates the practicality of the proposed sensor.
由于实施了监管限制，以防止双酚 A（BPA）对人体健康造成风险，其结构类似物双酚 F（BPF）已作为替代品进入市场。但是，最近的研究表明 BPF 是一种有效的内分泌干扰物。因此，有必要研究 BPF 的人体和环境暴露水平。在这项工作中，我们开发了一种经济的电化学传感器，使用氧化锌还原氧化石墨烯纳米复合材料（ZnO/G）和十六烷基三甲基溴化铵（CTAB）修饰的碳糊电极（CPE）来定量和详细研究 BPF 的电化学行为。ZnO/G 是通过 Hummers 法合成的，并通过光谱技术进行了表征。在最佳条件下，导电且生物相容的 ZnO/G/CTAB/MCPE 通过差分脉冲伏安法（DPV）对 BPF 的识别提供了超高灵敏度，检测限为 0.06 μM。BPF 电氧化的活化能降低和干扰分子抗坏血酸（AA）的峰不存在，使它成为 BPF 检测的独特传感器，与文献中报道的其他电极相比具有显著的分析优势。通过将其应用于人体体液、罐装饮料和不同加标 BPF 的水样的实时分析，证明了电极的多功能性。获得的令人满意的回收率，因此验证了所提出传感器的实用性。
